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1. (WO1992010516) 38-DECARBOXY-38-HYDROXYMETHYL DERIVATIVES OF TEICOPLANIN ANTIBIOTICS, AND A PROCESS FOR PREPARING THEM
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/010516 International Application No.: PCT/EP1991/002097
Publication Date: 25.06.1992 International Filing Date: 06.11.1991
Chapter 2 Demand Filed: 02.06.1992
IPC:
A61K 38/00 (2006.01) ,C07K 9/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
9
Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
Applicants:
GRUPPO LEPETIT S.P.A. [IT/IT]; Via G. Murat, 23 I-20159 Milano, IT (AllExceptUS)
MALABARBA, Adriano [IT/IT]; IT (UsOnly)
CIABATTI, Romeo [IT/IT]; IT (UsOnly)
Inventors:
MALABARBA, Adriano; IT
CIABATTI, Romeo; IT
Agent:
PIMPINELLI, Natale; Gruppo Lepetit S.p.A. Patent & Trademark Dept. Via R. Lepetit, 34 I-21040 Gerenzano, IT
Priority Data:
90123299.105.12.1990EP
Title (EN) 38-DECARBOXY-38-HYDROXYMETHYL DERIVATIVES OF TEICOPLANIN ANTIBIOTICS, AND A PROCESS FOR PREPARING THEM
(FR) DERIVES 38-DECARBOXY-38-HYDROXYMETHYLES D'ANTIBIOTIQUES A TEICOPLANINE, ET PROCEDE DE PREPARATION
Abstract:
(EN) The present invention is directed to novel 38-decarboxy-38-hydroxymethyl derivatives of teicoplanin antibiotics and a process for preparing them which comprises submitting the corresponding lower alkyl ester precursor to a reduction reaction in the presence of an alkali metal borohydride. The compounds of the invention show an improved antibacterial activity against some clinical isolates of $i(Staphylococci) somewhat resistant to teicoplanin.
(FR) Nouveaux dérivés 38-décarboxy-38-hydroxyméthyle d'antibiotiques à téicoplanine, et procédé de préparation consistant à soumettre le précurseur correspondant d'ester alkyle inférieur à une réaction de réduction en présence d'un hydrure de bore d'un métal alcalin. Ces composés présentent une activité antibactérienne améliorée dirigée contre certains isolats cliniques des staphylocoques qui présentent une certaine résistance à la téicoplanine.
Designated States: AU, CA, HU, JP, KR, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0560795US5869449JPH06503306CA2095725DE000069117304KR1019930703357
AU1991088651