Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO1992010474) 3-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY]-1-AZETIDINE CARBOXAMIDES HAVING ANTICONVULSANT ACTIVITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/010474 International Application No.: PCT/US1991/008647
Publication Date: 25.06.1992 International Filing Date: 14.11.1991
Chapter 2 Demand Filed: 09.06.1992
IPC:
C07D 205/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
205
Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
Applicants:
A.H. ROBINS COMPANY, INCORPORATED [US/US]; 1407 Cummings Drive Richmond, VA 23261-6609, US
Inventors:
TAYLOR, Chandler, Roy, Jr.; US
CALE, Albert, Duncan, Jr.; US
STAUFFER, Harold, Fisher, Jr.; US
Agent:
ALICE, Ronald, W.; American Home Products Corporation Five Giralda Farms Madison, NJ 07940-0874 , US
PORTER, Graham, Ronald ; Wyeth Laboratories Patents & Trademarks Department Huntercombe Lane South Taplow Nr Maidenhead Berks SL6 0PH, GB
Priority Data:
623,51707.12.1990US
Title (EN) 3-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY]-1-AZETIDINE CARBOXAMIDES HAVING ANTICONVULSANT ACTIVITY
(FR) CARBOXAMIDES DE 3-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY]-1-AZETIDINE AYANT UNE ACTION ANTICONVULSIVE
Abstract:
(EN) The present invention relates to novel 3-(2-chloro-4-trifluoromethylphenoxy)-1-azetidine carboxamides having formula (I), wherein R1 and R2, same or different, are selected from hydrogen, C1-C4 alkyl, and allyl. In a series of 3-(substituted phenoxy)-1-azetidinecarboxamides, introduction of a chlorine atom at the 2-position of the phenoxy group of the corresponding 4-trifluoromethylphenoxy-1-azetidinecarboxamides resulted in unexpected increased potency in anticonvulsant pharmacological tests.
(FR) L'invention se rapporte à de nouveaux carboxamides de 3-(2-chloro-4-trifluorométhylphénoxy)-1-azétidine, représentés par la formule (I), où R1 et R2, qui peuvent être identiques ou différents, sont choisis parmi hydrogène, alkyle C1-C4 et allyle. Dans une série de carboxamides de 3-(phénoxy substitué)-1-azétidine, l'introduction d'un atome de chlore à la position 2 du groupe phénoxy des carboxamides de 4-trifluorométhylphénoxy-1-azétidine correspondants s'est traduite dans des tests pharmacologiques par une augmentation inattendue de la puissance anticonvulsive de ces composés.
Designated States: AU, CA, FI, HU, JP, KR, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0560905JPH06503324CA2097835AU1991090840