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1. (WO1992010466) HEXADENTATE LIGANDS USEFUL IN RADIOGRAPHIC IMAGING AGENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/010466 International Application No.: PCT/US1991/009406
Publication Date: 25.06.1992 International Filing Date: 11.12.1991
IPC:
A61K 51/04 (2006.01) ,C07B 59/00 (2006.01) ,C07C 229/16 (2006.01) ,C07F 9/50 (2006.01) ,C07F 13/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59
Introduction of isotopes of elements into organic compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
229
Compounds containing amino and carboxyl groups bound to the same carbon skeleton
02
having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
04
the carbon skeleton being acyclic and saturated
06
having only one amino and one carboxyl group bound to the carbon skeleton
10
the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
16
to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
50
Organo-phosphines
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
13
Compounds containing elements of the 7th Group of the Periodic System
Applicants:
MALLINCKRODT MEDICAL, INC. [US/US]; 675 McDonnell Blvd. P.O. Box 5840 St. Louis, MO 63134, US
Inventors:
NEUMANN, William, L.; US
RAJAGOPALAN, Raghavan; US
Agent:
KLOSTERMANN, Roy, J. ; Mallinckrodt Medical, Inc. 675 McDonnell Blvd. P.O. Box 5840 St. Louis, MO 63134, US
Priority Data:
627,17614.12.1990US
Title (EN) HEXADENTATE LIGANDS USEFUL IN RADIOGRAPHIC IMAGING AGENTS
(FR) LIGANDS HEXADENTES UTILES DANS DES AGENTS D'IMAGERIE RADIOGRAPHIQUES
Abstract:
(EN) The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes. They have general formula (I), wherein R1 and R3 are the same or different and are selected from the group consisting of hydrogen, alkyl, aryl hydroxyl, alkoxyl, mono- or poly- hydroxyalkyl, mono- or poly- alkoxyalkyl, alkoxycarbonyl or carbamoyl; l and m may be the same or different and are from 2 to 5; Q and Z may be the same or different and are an O, N or S atom; and X and Y may be the same or different and are selected from the group consisting of (a), wherein R4-R6 may be the same or different and are selected from the group consisting of hydrogen, alkyl, aryl, hydroxyl, alkoxyl, mono- or poly- hydroxyalkyl, mono- or poly- alkoxy-alkyl, alkoxycarbonyl, amino, alkylamino, aminoalkyl, or carbamoyl.
(FR) Nouveaux ligands hexadentés préorganisés permettant la formation d'un complexe avec un radionuclide et utiles comme agents d'imagerie généraux à des fins de diagnostic. Lesdits ligands ont la formule générale (I) dans laquelle R1 et R3 sont identiques ou différents et ils sont sélectionnés dans le groupe constitué par hydrogène, alkyle, aryle, hydroxyle, alcoxy, mono ou polyhydroxyalkyle, mono ou polyalcoxyalkyle, alcoxycarbonyle ou carbamoyle; l et m peuvent être identiques ou différents et ils sont compris entre 2 et 5; Q et Z peuvent être identiques ou différents et ils représentent un atome O, N, ou S; et X ainsi que Y peuvent être identiques ou différents, ils sont sélectionnés dans le groupe (a) dans lequel R4 à R6 peuvent être identiques ou différents et sont sélectionnés dans le groupe constitué par hydrogène alkyle, aryle, hydroxyle, alcoxy, mono ou polyhydroalkyle, mono ou polyalkoxyalkyle, alcoxycarbonyle, amino, alkylamino, aminoalkyle ou carbamoyle.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0515670JPH05505624CA2076016AU1991091502