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1. (WO1992010461) PROCESS FOR THE PREPARATION OF DERIVATIVES OF 3,5-DIHYDROXY PENTANOIC ACID
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/010461 International Application No.: PCT/FR1991/000989
Publication Date: 25.06.1992 International Filing Date: 10.12.1991
Chapter 2 Demand Filed: 13.04.1992
IPC:
C07C 67/31 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
67
Preparation of carboxylic acid esters
30
by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
31
by introduction of functional groups containing oxygen only in singly bound form
Applicants:
RHONE-POULENC RORER S.A. [FR/FR]; 20, avenue Raymond-Aron F-92160 Antony, FR (AllExceptUS)
LEON, Patrick [FR/FR]; FR (UsOnly)
MASSONEAU, Viviane [FR/FR]; FR (UsOnly)
RADISSON, Xavier [FR/FR]; FR (UsOnly)
Inventors:
LEON, Patrick; FR
MASSONEAU, Viviane; FR
RADISSON, Xavier; FR
Agent:
PILARD, Jacques; Rhône-Poulenc Rorer S.A. 20, avenue Raymond-Aron F-92165 Antony Cédex, FR
Priority Data:
90/1546911.12.1990FR
Title (EN) PROCESS FOR THE PREPARATION OF DERIVATIVES OF 3,5-DIHYDROXY PENTANOIC ACID
(FR) PROCEDE DE PREPARATION DE DERIVES DE L'ACIDE DIHYDROXY-3,5 PENTANOIQUE
Abstract:
(EN) Process for the preparation of products having general formula (I) by stereoselective reduction of an hydroxyketone having the general formula (II) with the aid of borohydride or sodium or potassium cyanoborohydride associated with a titanium derivative. In formulae (I and II), z is an alkoxy, alkylthio, amino, alkylamino, dialkylamino radical, R is: either a R1-Y-(-Y-=-CH2CH2-,-CH=CH-,-C=C-radical and R1 is an optionally substituted aliphatic alicyclic, aromatic or heteroaromatic radical) or a radical (a) (R2=halogen, alkoxy, alkylthio, arylthio, amino, alkylamino, dialkylamino and R3=hydrogen or R2).
(FR) Procédé de préparation de produits de formule genérale (I) par réduction stéréosélective d'une hydroxycétone de formule générale (II) au moyen de borohydrure ou de cyanoborohydrure de sodium ou de potassium associé à un dérivé du titane. Dans les formules (I) et (II), Z représente un radical alcoxy, alcoylthio, amino, alcoylamino, dialcoylamino, R représente: soit un radical R1-Y-(-Y-=-CH2CH2-, -CH=CH-,-C=C- et R1 représente un radical aliphatique, alicyclique, aromatique ou hétéroaromatique éventuellement substitué) - soit un radical (a) (R2=halogène, alcoxy, alcoylthio, arylthio, amino, alcoylamino, dialcoylamino et R3=hydrogène ou R2).
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE)
Publication Language: French (FR)
Filing Language: French (FR)
Also published as:
EP0561985US5347039JPH06503571CA2098185AU1991091420FR2670206