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1. (WO1992010214) METHOD OF RADIOACTIVE LABELLING OF BLOOD CELLS AND KIT THEREFOR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/010214 International Application No.: PCT/US1991/009244
Publication Date: 25.06.1992 International Filing Date: 11.12.1991
Chapter 2 Demand Filed: 13.05.1992
IPC:
A61K 51/04 (2006.01) ,A61K 51/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
12
characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
Applicants:
MALLINCKRODT MEDICAL, INC. [US/US]; 675 McDonnell Blvd. P.O. Box 5840 St. Louis, MO 63134, US (AllExceptUS)
GOEDEMANS, Wim, Th. [NL/NL]; NL (UsOnly)
Inventors:
GOEDEMANS, Wim, Th.; NL
Agent:
WITT, Evan, R. ; Mallinckrodt Medical, Inc. 675 McDonnell Blvd. P.O. Box 5840 St. Louis, MO 63134, US
Priority Data:
90203266.312.12.1990EP
Title (EN) METHOD OF RADIOACTIVE LABELLING OF BLOOD CELLS AND KIT THEREFOR
(FR) PROCEDE DE MARQUAGE ISOTOPIQUE DE CELLULES DU SANG ET KIT POUR CE FAIRE
Abstract:
(EN) The invention relates to a method of radioactive labelling of blood cells by treating a suspension of blood cells with a composition, obtained by adding a Tc-99m pertechnetate solution to a mixture of (i) a metallic reducing agent, (ii) an exchange ligand, (iii) a suitable buffer, if desired, and (iv) a dithiocarbamate, or to an at least substantially aqueous solution of said mixture; and by then incubating the reaction mixture so obtained, preferably at room temperature. The invention further relates to a composition for the radioactive labelling of blood cells, and to a kit therefor.
(FR) Cette invention concerne un procédé de marquage isotopique des cellules du sang. Dans ce procédé, on traite une suspension de cellules sanguines avec une composition que l'on obtient en ajoutant une solution de pertechnétate Tc-99m à un mélange comprenant (1) un agent métallo-réducteur, (ii) un ligand échangeur, (iii) un tampon approprié, si nécessaire, et (iv) un dithiocarbamate ou en ajoutant ladite solution à une solution au moins partiellement aqueuse dudit mélange; puis on fait incuber le mélange de réaction ainsi obtenu, de préférence dans des conditions de température ambiante. Cette invention concerne également une composition destinée au marquage isotopique des cellules sanguines et un kit pour effectuer ce marquage isotopique.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1991091721