Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO1992010190) NOVEL CSAIDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/010190 International Application No.: PCT/US1991/009416
Publication Date: 25.06.1992 International Filing Date: 12.12.1991
Chapter 2 Demand Filed: 13.07.1992
IPC:
C07D 471/04 (2006.01) ,C07D 487/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
SMITHKLINE BEECHAM CORPORATION [US/US]; 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406, US (AllExceptUS)
ADAMS, Jerry, Leroy [US/US]; US (UsOnly)
GALLAGHER, Timothy, F. [US/US]; US (UsOnly)
Inventors:
ADAMS, Jerry, Leroy; US
GALLAGHER, Timothy, F.; US
Agent:
DINNER, Dara, L. ; SmithKline Beecham Corporation Corporate Intellectual Property, UW2220 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406-0939, US
Priority Data:
626,81313.12.1990US
Title (EN) NOVEL CSAIDS
(FR) NOUVEAUX MEDICAMENTS ANTI-INFLAMMATOIRES SUPPRESSEURS DE CYTOKINE
Abstract:
(EN) The novel compounds of formula (I) bicyclo 5,6-Dihydro-7$i(H)-pyrrolo-[1,2-a]-imidazol-7-ol and 7-one substituted ring systems, have been found to be useful cytokine suppressive agents, and inhibitors of the 5-lipoxygenase and cyclooxygenase enzymes and therefore useful in the treatment and prophylaxis of disease states mediated thereby.
(FR) On a découvert que les nouveaux composés de la formule (I), des systèmes cycliques à substitution bicyclo 5,6-dihydro-7$i(H)-pyrrolo-[1,2-a]-imidazole-7-ol et 7-one, sont des agents suppresseurs de cytokine utiles, ainsi que des inhibiteurs des enzymes 5-lipoxygénase et cycloxygénase, et qui sont par conséquent utiles dans le traitement et la prophylaxie d'états pathologiques ainsi induits.
Designated States: AU, CA, JP, KR, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0565582JPH06504779CA2098177KR1019930703321AU1991091375