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1. (WO1992010176) THERAPEUTIC AGENT FOR HEPATIC DISEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/010176 International Application No.: PCT/JP1991/001700
Publication Date: 25.06.1992 International Filing Date: 07.12.1991
Chapter 2 Demand Filed: 06.07.1992
IPC:
A61K 31/215 (2006.01) ,A61K 31/225 (2006.01) ,A61K 31/36 (2006.01) ,A61K 31/425 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
22
of acyclic acids, e.g. pravastatin
225
Polycarboxylic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
357
having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
36
Compounds containing methylenedioxyphenyl groups, e.g. sesamin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
Applicants:
TAISHO PHARMACEUTICAL CO., LTD. [JP/JP]; 24-1, Takata 3-chome Toshima-ku Tokyo 171, JP (AllExceptUS)
NIPPON ZEON CO., LTD. [JP/JP]; 6-1, Marunouchi 2-chome Chiyoda-ku Tokyo 100, JP (AllExceptUS)
OTOMO, Susumu [JP/JP]; JP (UsOnly)
HIGUCHI, Shohei [JP/JP]; JP (UsOnly)
ARAI, Iwao [JP/JP]; JP (UsOnly)
OHNAKA, Michihiro [JP/JP]; JP (UsOnly)
MATSUNO, Shugo [JP/JP]; JP (UsOnly)
MISAWA, Mari [JP/JP]; JP (UsOnly)
Inventors:
OTOMO, Susumu; JP
HIGUCHI, Shohei; JP
ARAI, Iwao; JP
OHNAKA, Michihiro; JP
MATSUNO, Shugo; JP
MISAWA, Mari; JP
Agent:
NISHIZAWA, Toshio; 208, Shibuya-Homes 2-1, Udagawa-cho Shibuya-ku Tokyo 150, JP
Priority Data:
2/40091807.12.1990JP
Title (EN) THERAPEUTIC AGENT FOR HEPATIC DISEASE
(FR) AGENT THERAPEUTIQUE CONTRE LES MALADIES DU FOIE
Abstract:
(EN) A therapeutic agent for hepatic diseases, which contains a malonic acid derivative represented by the general formula (I) as the active ingredient. In said formula, A represents hydrogen, or an optionally substituted lower aliphatic, cycloaliphatic, aromatic or heterocyclic group; R1 represents lower alkoxy or halogenated phenyl; R2 represents lower alkyl; and n represents a number of 0 or 1.
(FR) Agent thérapeutique contre les maladies du foie, contenant un dérivé de l'acide malonique représenté par la formule générale (I) en tant qu'ingrédient actif. Dans la formule, A représente hydrogène, ou un groupe aliphatique inférieur, cycloaliphatique, aromatique ou hétérocyclique éventuellement substitué; R1 représente alcoxy inférieur ou phényle halogéné; R2 représente alkyle inférieur; n vaut 0 ou 1.
Designated States: CA, JP, KR, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)