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1. (WO1992010173) PHARMACEUTICAL COMPOSITIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/010173 International Application No.: PCT/US1991/009221
Publication Date: 25.06.1992 International Filing Date: 04.12.1991
Chapter 2 Demand Filed: 02.07.1992
IPC:
A61K 9/16 (2006.01) ,A61K 9/50 (2006.01) ,A61K 31/415 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
Applicants:
SMITHKLINE BEECHAM CORPORATION [US/US]; Corporate Patents - U.S. 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406, US (AllExceptUS)
MARSHALL, Keith [US/US]; US (UsOnly)
THIELE, William, Jay [US/GB]; GB (UsOnly)
Inventors:
MARSHALL, Keith; US
THIELE, William, Jay; GB
Agent:
DINNER, Dara, L. ; SmithKline Beecham Corporation Corporate Intellectual Property, UW2220 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406-0939, US
VENETIANER, Stephen; SmithKline Beecham Corporation Corporate Patents - U.S. 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406, US
Priority Data:
622,87505.12.1990US
Title (EN) PHARMACEUTICAL COMPOSITIONS
(FR) COMPOSITIONS PHARMACEUTIQUES
Abstract:
(EN) The present invention provides for a phased-release oral dosage form comprising a plurality of H2 receptor antagonist pellets in a polymer matrix. Each phase, containing a plurality of pellets which may be optionally coated with a release delaying substance, may have different release rates, thereby providing release of the H2 antagonist over an extended duration of time.
(FR) L'invention se rapporte à un dosage oral à phase de libération modifiée, comprenant une pluralité de granules antagonistes au récepteur H2 contenus dans une matrice polymère. Chaque phase, contenant une pluralité de granules pouvant être éventuellement revêtus d'une substance provoquant un effet retard, peut présenter différentes cadences de libération, ce qui permet de libérer l'antagoniste de H2 sur une durée prolongée.
Designated States: AU, CA, JP, KR, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXPA/a/1991/002413EP0560937JPH06503577CA2097495KR1019930702961AU1991091641