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1. (WO1992009895) COMPOSITION AND ITS PREPARATION PROCESS USING ANTIGEN CONJUGATED TO ENZYMATIC ACTIVITY FOR IMMUNOLOGICAL DIAGNOSIS AND CHAGAS' DISEASE IMMUNOLOGICAL DIAGNOSIS KITS, FOR INDIVIDUAL AND EPIDEMIOLOGICAL APPLICATION, BASED ON THAT COMPOSITION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009895 International Application No.: PCT/BR1991/000027
Publication Date: 11.06.1992 International Filing Date: 28.11.1991
IPC:
G01N 33/535 (2006.01) ,G01N 33/569 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
531
Production of immunochemical test materials
532
Production of labelled immunochemicals
535
with enzyme label
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
Applicants:
FUNDAÇÃO OSWALDO CRUZ (FIOCRUZ) - SUPERINTENDÊNCIA DE PLANEJAMENTO [BR/BR]; Avenida Brasil, Nº 4365 Prédio Quinino, Sala 305, Manguinhos 21040-Rio de Janeiro, RJ, BR (AllExceptUS)
CERQUEIRA DE ALMEIDA, Elza, Carmen [BR/BR]; BR (UsOnly)
KRIEGER, Marco, Aurélio [BR/BR]; BR (UsOnly)
GOLDENBERG, Samuel [BR/BR]; BR (UsOnly)
Inventors:
CERQUEIRA DE ALMEIDA, Elza, Carmen; BR
KRIEGER, Marco, Aurélio; BR
GOLDENBERG, Samuel; BR
Priority Data:
900603928.11.1990BR
Title (EN) COMPOSITION AND ITS PREPARATION PROCESS USING ANTIGEN CONJUGATED TO ENZYMATIC ACTIVITY FOR IMMUNOLOGICAL DIAGNOSIS AND CHAGAS' DISEASE IMMUNOLOGICAL DIAGNOSIS KITS, FOR INDIVIDUAL AND EPIDEMIOLOGICAL APPLICATION, BASED ON THAT COMPOSITION
(FR) COMPOSITION COMPRENANT DES ANTIGENES CONJUGUES A UNE ACTIVITE ENZYMATIQUE, ET DESTINEE AUX NECESSAIRES A USAGE PRIVE ET EPIDEMIOLOGIQUE DE DIAGNOSTIC IMMUNOLOGIQUE, NOTAMMENT DE LA MALADIE DE CHAGAS, ET PROCEDE DE PREPARATION DE LADITE COMPOSITION
Abstract:
(EN) This patent deals with the use of antigens conjugated to an enzymatic activity for the detection of immune-complexes against antigenic mixtures containing conjugated antigen, hence allowing the detection of antibodies even with low titre, through the development of a color reaction. The method is based on the specificity of antibodies and can be used for the diagnosis of any infectious disease with the condition of using the appropriate conjugated antigen. The diagnosis kits for Chagas' disease make use of the recombinant $i(Trypanosoma cruzi) antigens described in the patent application PCT/BR/91/00003, (Brazilian application number 9001479, of MAR, 30, 1990), and are indicated for the immunological diagnosis of Chagas' disease using either ELISA or the antigens immobilized to solid supports such as nitrocellulose, nylon, polyvinyl, polycarbonate and polyallomer.
(FR) On décrit l'utilisation d'antigènes conjugués à une activité enzymatique pour la détection de complexes immuns dressés contre les mélanges antigéniques qui renferment des antigènes conjugués, ce qui permet la détection même des anticorps à faible titre grâce à l'élaboration d'une réaction colorée. Le procédé est basé sur la spécificité des anticorps et peut servir au diagnostic de toutes les maladies infectieuses à condition que l'on se serve de l'antigène conjugué approprié. Les nécessaires destinés au diagnostic de la maladie de Chagas utilisent les antigènes recombinés de $i(Trypanosoma cruzi) décrits dans la demande de brevet PCT/BR 91/00003 (demande brésilienne numéro 9001479 du 30 mars 1990), et sont indiqués dans le diagnostic immunologique de la maladie de Chagas à l'aide soit de la technique ELISA soit des antigènes immobilisés sur des supports solides tels que la pyroxyline, le nylon, le polyvinyle, le polycarbonate et le polyallomère.
Designated States: US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0514509