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1. (WO1992009705) TRIPLEX-FORMING OLIGOMERS CONTAINING MODIFIED BASES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009705 International Application No.: PCT/US1991/008811
Publication Date: 11.06.1992 International Filing Date: 25.11.1991
Chapter 2 Demand Filed: 04.06.1992
IPC:
C07H 21/00 (2006.01) ,C12Q 1/68 (2006.01) ,C12Q 1/70 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
70
involving virus or bacteriophage
Applicants:
GILEAD SCIENCES, INC. [US/US]; 344 Lakeside Drive Foster City, CA 94404, US
Inventors:
FROEHLER, Brian; US
KRAWCZYK, Steven; US
MATTEUCCI, Mark, D.; US
MILLIGAN, John; US
Agent:
MURASHIGE, Kate, H. ; Morrison & Foerster 545 Middlefield Road Suite 200 Menlo Park, CA 94025, US
Priority Data:
617,90723.11.1990US
643,38218.01.1991US
683,42008.04.1991US
686,54417.04.1991US
686,54617.04.1991US
686,54717.04.1991US
766,73327.09.1991US
Title (EN) TRIPLEX-FORMING OLIGOMERS CONTAINING MODIFIED BASES
(FR) OLIGOMERES FORMANT UN TRIPLEX ET CONTENANT DES BASES MODIFIEES
Abstract:
(EN) Oligomers containing at least one modified nucleotide residue that specifically forms a triplet with the G-C doublet in forming a triplex with a target DNA duplex are disclosed which maintain this binding at neutral pH. The modified nucleotide residues have base components which provide donor H to each of the acceptable electron pairs at positions O6 and N7 of G at neutral pH. The oligomers may also have regions of inverted polarity and/or crosslinking moieties.
(FR) Oligomères contenant au moins un résidu de nucléotide modifié qui forme spécifiquement un triplet avec le doublet G-C en constituant un triplex avec un duplex d'ADN cible, qui maintiennent cette liaison à un pH neutre. Lesdits résidus de nucléotide modifiés possèdent des composants de base qui fournissent un donneur H à chacune des paires d'électrons acceptables aux positions O6 et N7 de G à un pH neutre. Lesdits oligomères peuvent également comporter des régions de polarité inversée et/ou à fractions réticulantes.
Designated States: AU, CA, FI, JP, KR, NO, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0558634AU1991090949