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1. (WO1992009697) USE OF A BONE MORPHOGENETIC PROTEIN IN SYNERGISTIC COMBINATION WITH TGF-$g(b) FOR BONE REPAIR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009697 International Application No.: PCT/US1991/008953
Publication Date: 11.06.1992 International Filing Date: 27.11.1991
IPC:
A61K 38/00 (2006.01) ,A61K 38/18 (2006.01) ,C07K 14/495 (2006.01) ,C07K 14/51 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
495
Transforming growth factor (TGF)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
51
Bone morphogenic factor; Osteogenin; Osteogenic factor; Bone-inducing factor
Applicants:
CELTRIX LABORATORIES, INC. [US/US]; 2500 Faber Place Palo Alto, CA 94303, US
Inventors:
BENTZ, Hanne; US
THOMPSON, Andrea, Y.; US
ARMSTRONG, Rosa; US
ROSEN, David, M.; US
Agent:
BENZ, William, H. ; Morrison & Foerster 545 Middlefield Road Suite 200 Menlo Park, CA 94025, US
Priority Data:
620,14230.11.1990US
Title (EN) USE OF A BONE MORPHOGENETIC PROTEIN IN SYNERGISTIC COMBINATION WITH TGF-$g(b) FOR BONE REPAIR
(FR) UTILISATION EN OSTEOPATHIE D'UNE PROTEINE MORPHOGENETIQUE D'ORIGINE OSSEUSE ASSOCIEE DE MANIERE SYNERGIQUE AVEC DU BETA DE FACTEUR DE CROISSANCE DE TRANSFORMATION ($g(b)-FCT).
Abstract:
(EN) Bone morphogenetic proteins (BMPs) work in synergistic combination with TGF-$g(b)s to provide compositions with increased osteogenic activity. Methods of treating bone defects, inducing bone growth and increasing bone marrow cell production using these compositions are also disclosed.
(FR) Protéines morphogénétiques d'origine osseuse (PMO) associées de manière synergique à des bêta - FCT pour produire des compositions ayant une activité ostéogénique améliorée. Cette invention concerne également des procédés permettant de traiter des imperfections osseuses en stimulant la croissance osseuse et en augmentant la production de cellules de la moelle osseuse.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0513334JP3356775JPH05505404CA2071912AU1991091419