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1. (WO1992009691) NEW VARIANTS DERIVED FROM INTERFERONS OF TYPE I, PRODUCTION PROCESS THEREOF AND THEIR APPLICATIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009691 International Application No.: PCT/FR1991/000953
Publication Date: 11.06.1992 International Filing Date: 29.11.1991
IPC:
A61K 38/00 (2006.01) ,C07K 14/56 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
555
Interferons (IFN)
56
IFN-alpha
Applicants:
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE - I.N.R.A. [FR/FR]; 147, rue de l'Université F-75341 Paris Cédex 07, FR (AllExceptUS)
MARTAL, Jacques [FR/FR]; FR (UsOnly)
DEGRYSE, Eric [BE/FR]; FR (UsOnly)
GAYE, Pierre [FR/FR]; FR (UsOnly)
CHARLIER, Madia [FR/FR]; FR (UsOnly)
CHARPIGNY, Gilles [FR/FR]; FR (UsOnly)
REINAUD, Pierrette [FR/FR]; FR (UsOnly)
CHAOUAT, Gérard [FR/FR]; FR (UsOnly)
Inventors:
MARTAL, Jacques; FR
DEGRYSE, Eric; FR
GAYE, Pierre; FR
CHARLIER, Madia; FR
CHARPIGNY, Gilles; FR
REINAUD, Pierrette; FR
CHAOUAT, Gérard; FR
Agent:
ORES, Irène ; Cabinet Ores 6, avenue de Messine F-75008 Paris, FR
Priority Data:
90/1494529.11.1990FR
90/1494629.11.1990FR
Title (EN) NEW VARIANTS DERIVED FROM INTERFERONS OF TYPE I, PRODUCTION PROCESS THEREOF AND THEIR APPLICATIONS
(FR) NOUVEAUX VARIANTS DERIVES DES INTERFERONS DE TYPE I, LEUR PROCEDE DE PRODUCTION, ET LEURS APPLICATIONS
Abstract:
(EN) The invention relates to new variants of type I interferon having one of the following formulae: X1-R0 (I); or X1-X2-R0 (II); or X1-X2-X3-R0 (III) wherein X1, X2 and X3 are similar or different and represent each an amino acid and Ro is the amino acid sequence of an interferon of type I, a cassette enabling their expression in the yeast, the invention also relating to the method for producing such variants from yeasts transformed by said cassette, as well as to their applications.
(FR) L'invention est relative à de nouveaux variants d'interféron de type I, répondant à l'une des formules suivantes: X1-R0 (I) ou bien X1-X2-R0 (II) ou bien X1-X2-X3-R0 (III) dans laquelle X1, X2 et X3 sont identiques ou différents, et représentent chacun un acide aminé et R0 représente la séquence en acides aminés de la forme mature d'un interféron de type I, une cassette permettant leur expression dans la levure, à leur procédé de production à partir de levures transformées par ladite cassette, et à leurs applications.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: French (FR)
Filing Language: French (FR)
Also published as:
EP0513336US5378823JP3366947JPH05504069CA2074802AU1991091305