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1. (WO1992009630) IMIDOESTER CROSS-LINKED HEMOGLOBIN COMPOSITIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009630 International Application No.: PCT/US1991/007155
Publication Date: 11.06.1992 International Filing Date: 03.10.1991
Chapter 2 Demand Filed: 04.06.1992
IPC:
A61K 38/00 (2006.01) ,C07K 14/805 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
795
Porphyrin- or corrin-ring-containing peptides
805
Haemoglobins; Myoglobins
Applicants:
THE UPJOHN COMPANY [US/US]; 301 Henrietta Street Kalamazoo, MI 49001, US (AllExceptUS)
GARLICK, Robert, Lee [US/US]; US (UsOnly)
MARTIN, Joseph, Patrick, Jr. [US/US]; US (UsOnly)
LYLE, Stephen, Baker [US/US]; US (UsOnly)
Inventors:
GARLICK, Robert, Lee; US
MARTIN, Joseph, Patrick, Jr.; US
LYLE, Stephen, Baker; US
Agent:
CORNEGLIO, Donald, L.; The Upjohn Company Corporate Patents & Trademarks 301 Henrietta Street Kalamazoo, MI 49001, US
PERRY, Robert, E.; Gill Jennings & Every 53-64 Chancery Lane London WC2A 1HN, GB
Priority Data:
619,84029.11.1990US
Title (EN) IMIDOESTER CROSS-LINKED HEMOGLOBIN COMPOSITIONS
(FR) COMPOSITIONS D'HEMOGLOBINE RETICULEES PAR UN IMIDOESTER
Abstract:
(EN) An imidoester, cross-linked hemoglobin composition useful in the transport of oxygen to living cells and being essentially free of any impurities, a P50 of at least 13 mM Hg and predominantly in tetramer form. Preferably, the cross-linked hemoglobin composition has a predominant molecular weight of at least 64,000. The purified and cross-linked hemoglobin has improved cross-link stability to autoxidation and can be used as a blood substitute for mammals or as an oxygen transport fluid.
(FR) Composition d'hémoglobine réticulée par une imidoester utilisée dans le transport d'oxygène vers des cellules vivantes et exemptes de toute impureté, présentant un P 50 de Hg d'au moins 13 mM et dont la forme prédominante est celle d'un tétramère. De préférence, la composition d'hémoglobine réticulée a une masse moléculaire prédominante d'au moins 64000. L'hémoglobine purifiée et réticulée a une stabilité de réticulation améliorée à l'auto-oxydation et elle peut être utilisée pour remplacer le sang chez des mammifères ou comme fluide de transport d'oxygène.
Designated States: AU, BB, BG, BR, CA, CS, FI, HU, JP, KP, KR, LK, MC, MG, MN, MW, NO, PL, RO, SD, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1993-854FI932461NO19931956SK54993IL99785EP0559655
US5362855JPH06502848CA2093650AU1991085466