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1. (WO1992009617) CELL STRESS TRANSCRIPTIONAL FACTORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009617 International Application No.: PCT/US1991/008592
Publication Date: 11.06.1992 International Filing Date: 22.11.1991
Chapter 2 Demand Filed: 22.11.1991
IPC:
C07K 14/435 (2006.01) ,C07K 14/47 (2006.01) ,C07K 16/18 (2006.01) ,C12N 15/67 (2006.01) ,C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
67
General methods for enhancing the expression
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, U.S. DEPARTMENT OF COMMERCE [US/US]; 5285 Port Royal Road Springfield, VA 22161, US
Inventors:
WU, Carl; US
CLOS, Joachim; US
WESTWOOD, J., Timothy; US
RABINDRAN, Sridhar; US
Agent:
HOLMAN, John, Clarke ; Fleit, Jacobson, Cohn, Price, Holman & Stern The Jenifer Building 400 Seventh Street, N.W. Washington, DC 20004, US
Priority Data:
617,91026.11.1990US
Title (EN) CELL STRESS TRANSCRIPTIONAL FACTORS
(FR) FACTEURS DE TRANSCRIPTION D'AGRESSION DE CELLULES
Abstract:
(EN) The present invention relates to DNA sequence coding for part or all of the heat shock transcription factor or heat shock factor (HSF) proteins derived from humans and Drosophila, and the proteins encoded by these sequences. The present invention also includes methods for detecting HSF in a biological sample. The presence of HSF in the nucleus of a cell can be detected with specific anti-HSF antibody reagents. The presence of such HSF proteins in the nucleus indicates a stressed condition including diseases. Furthermore, the presence of multimeric HSF in the crude or fractionated cell extract is indicative of a stressed state.
(FR) L'invention concerne une séquence d'ADN codant pour une partie ou l'ensemble des protéines constituant le facteur de transcription de choc thermique ou facteur de choc thermique (HSF), dérivées de l'homme et de la drosophile, ainsi que les protéines codées par ces séquences. L'invention comprend également des procédés de détection du HSF dans un échantillon biologique. La présence du HSF dans le noyau d'une cellule peut être détectée à l'aide de réactifs spécifiques aux anticorps anti-HSF. La présence de telles protéines constituant le HSF dans le noyau indique une condition d'agression y compris des maladies. En outre, la présence de HSF multimérique dans l'extrait de cellule brut ou fractionné indique unétat d'agression.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0559770JPH06502540CA2096975AU1991090723