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1. (WO1992009604) 6-AZIDO-2-FLUOROPURINE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009604 International Application No.: PCT/US1991/008838
Publication Date: 11.06.1992 International Filing Date: 29.11.1991
IPC:
C07D 473/40 (2006.01) ,C07H 19/16 (2006.01) ,C07H 19/20 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
40
with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
20
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
Applicants:
BERLEX BIOSCIENCES, INC. [US/US]; 110 E. Hanover Avenue Cedar Knolls, NJ 07927, US
Inventors:
BAUMAN, John, C.; US
WIRSCHING, Randolph, C.; US
Agent:
ZELANO, Anthony, J. ; Millen, White & Zelano Arlington Courthouse Plaza I Suite 1201 2200 Clarendon Boulevard Arlington, VA 22201, US
Priority Data:
620,23629.11.1990US
Title (EN) 6-AZIDO-2-FLUOROPURINE
(FR) 6-AZIDO-2-FLUOROPURINE
Abstract:
(EN) This invention pertains to novel methods of synthesizing fludarabine, fludarabine phosphate and related nucleoside pharmacologic agents utilizing 6-azido-2-fluoropurine as a novel intermediate. In particular this invention pertains to a synthesis of fludarabine where the relatively low yield fluorination step is done before the costly coupling step.
(FR) L'invention concerne de nouveaux procédés pour synthétiser la fludarabine, le phosphate de fludarabine et les agents pharmacologiques nucléosidiques apparentés à l'aide de la 6-azido-2-fluoropurine utilisée comme nouvel intermédiaire. Cette invention concerne en particulier un procédé de synthèse de la fludarabine selon lequel on procéde à l'étape de fluorination à rendement relativement bas avant de procéder à l'opération de couplage qui est coûteuse.
Designated States: JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)