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1. (WO1992009592) PROCESS FOR PREPARING MULTICYCLIC OXY-CONTAINING RING COMPONENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009592 International Application No.: PCT/US1991/006610
Publication Date: 11.06.1992 International Filing Date: 12.09.1991
Chapter 2 Demand Filed: 18.06.1992
IPC:
C07D 307/91 (2006.01) ,C07D 311/78 (2006.01) ,C07D 453/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77
ortho- or peri-condensed with carbocyclic rings or ring systems
91
Dibenzofurans; Hydrogenated dibenzofurans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
78
Ring systems having three or more relevant rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
453
Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02
containing not further condensed quinuclidine ring systems
Applicants:
RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. [US/US]; Delaware Corporate Center I 1 Righter Parkway Suite 114 Talleyville Wilmington, DE 19803, US (AllExceptUS)
AIREY, John, E. [GB/US]; US (UsOnly)
STUDT, William, L. [US/US]; US (UsOnly)
POWERS, Matthew, R. [US/US]; US (UsOnly)
WOODWARD, Rick, G. [US/US]; US (UsOnly)
GOLEC, Frederick, A. [US/US]; US (UsOnly)
RODRIGUEZ, Walter [US/US]; US (UsOnly)
Inventors:
AIREY, John, E.; US
STUDT, William, L.; US
POWERS, Matthew, R.; US
WOODWARD, Rick, G.; US
GOLEC, Frederick, A.; US
RODRIGUEZ, Walter; US
Agent:
NICHOLSON, James, A. ; Rhone-Poulenc Rorer Inc. 500 Arcola Road P.O. Box 1200 Collegeville, PA 19426-0107, US
Priority Data:
620,24029.11.1990US
Title (EN) PROCESS FOR PREPARING MULTICYCLIC OXY-CONTAINING RING COMPONENTS
(FR) PROCEDE POUR LA PREPARATION DE COMPOSES MULTICYCLIQUES A TENEUR EN OXY
Abstract:
(EN) This invention relates to stereospecific processes for the preparation, separation and purification of multicyclic oxy-containing ring system compounds such as dibenzofuran and benzoxocine-type compounds which exhibit 5HT3-antagonist properties including unique CNS, anti-emetic and gastric prokinetic activity and which are void of any significant D2 receptor binding affinity.
(FR) Procédés stéréospécifiques pour la préparation, la séparation et la purification de composés système multicycliques à teneur en oxy, tels que des composés du type dibenzofuranne et benzoxocine qui présentent des propriétés anti-5HT3, notamment une activité sur le système nerveux central, une activité procinétique gastrique et une activité antiémétique uniques en leur genre. En outre, lesdits composés n'ont aucune capacité de liaison significative de récepteur D2.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0559656JPH06502849CA2097190AU1991086593