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1. (WO1992009580) CHEMILUMINESCENT COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009580 International Application No.: PCT/US1991/006861
Publication Date: 11.06.1992 International Filing Date: 20.09.1991
IPC:
C07D 219/04 (2006.01) ,C07D 221/12 (2006.01) ,C07D 401/06 (2006.01) ,C07D 405/12 (2006.01) ,C07D 409/12 (2006.01) ,C07D 521/00 (2006.01) ,C07F 9/64 (2006.01) ,G01N 33/58 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
219
Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
04
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
221
Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/-C07D219/187
02
condensed with carbocyclic rings or ring systems
04
Ortho- or peri-condensed ring systems
06
Ring systems of three rings
10
Aza-phenanthrenes
12
Phenanthridines
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
521
Heterocyclic compounds containing unspecified hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
547
Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
553
having one nitrogen atom as the only ring hetero atom
576
Six-membered rings
64
Acridine or hydrogenated acridine ring systems
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58
involving labelled substances
Applicants:
BECKMAN INSTRUMENTS, INC. [US/US]; 2500 Harbor Boulevard Fullerton, CA 92634, US
Inventors:
REDDY, M., Parameswara; US
MICHAEL, Maged, Aziz; US
OH, Chan, S.; US
DOBASHI, Thomas, S.; US
GIRGIS, Nabih, S.; US
Agent:
MAY, William, H. ; Beckman Instruments, Inc. 2500 Harbor Boulevard Fullerton, CA 92634, US
Priority Data:
616,48621.11.1990US
Title (EN) CHEMILUMINESCENT COMPOUNDS
(FR) COMPOSES CHIMIOLUMINESCENTS
Abstract:
(EN) Novel chemiluminescent compounds are suitable for use in labeling biological molecules for assays such as immunoassays. These chemiluminescent labels are characterized by the incorporation of stable leaving groups. One class of these chemiluminescent labels comprises salts in which the leaving group contains a carboxyl carbon atom or its isoelectronic equivalent and a five-membered ring, including at least one heteroatom. The heteroatom is preferably oxygen or sulfur. This leaving group is linked to a positively charged moiety capable of producing light by chemiluminescence, which can be an acridinium, phenanthridinium, quinolinium, or benzacridinium moiety. Both the leaving group and the positively charged moiety can be substituted, such as with reactive substituents for covalently linking the label to a biological molecule. Substituents on the five-membered ring of the leaving group can form an additional ring. An additional class of these chemiluminescent labels comprises a chemical group that can produce light by chemiluminescence covalently linked to a leaving group comprising a moiety containing a sulfur, phosphorus, or carbon atom double-bonded to a more electronegative atom or atoms.
(FR) De nouveaux composés chimioluminescents sont appropriés pour être utilisés dans le marquage de molécules biologiques pour des analyses telles que des immunoanalyses. Ces marques chimioluminescentes se caractérisent par l'incorporation de groupes partants stables. Une classe de ces marques chimioluminescentes comprend des sels dans lesquels le groupe partant contient un atome de carbone carboxyle ou son équivalent isoélectronique et un cycle à cinq membres, y compris au moins un hétéroatome. L'hétéroatome est de préférence de l'oxygène ou du soufre. Ce groupe partant est lié à une fraction chargée positivement pouvant produire de la lumière par chimioluminescence, et peut-être une fraction d'acridinium, phénanthridinium, quinolinium ou benzacridinium. Tant le groupe partant que la fraction chargée positivement peuvent être substitués, par exemple avec des substituants réactifs pour associer de manière covalente l'étiquette ou marque à une molécule biologique. Des substituants sur le cycle à cinq membres du groupe partant peuvent former un cycle additionnel. Une classe additionnelle de ces marques chimioluminescentes comprend un groupe chimique qui peut produire de la lumière par chimioluminescence et relié par covalence à un groupe partant comprenant une fraction contenant un atome de soufre, de phosphore ou de carbone lié par une double liaison à un ou plusieurs atomes électronégatifs.
Designated States: JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0511366JPH05500010