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1. (WO1992009562) NOVEL X-RAY CONTRAST AGENTS, COMPOSITIONS AND METHODS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009562 International Application No.: PCT/US1991/001827
Publication Date: 11.06.1992 International Filing Date: 18.03.1991
Chapter 2 Demand Filed: 18.06.1992
IPC:
A61K 49/04 (2006.01) ,C07C 237/46 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
04
X-ray contrast preparations
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
237
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
28
having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
46
having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
Applicants:
MALLINCKRODT MEDICAL, INC. [US/US]; 675 McDonnel Boulevard P.O. Box 5840 St. Louis, MO 63134, US (AllExceptUS)
LIN, Youlin [US/US]; US (UsOnly)
WALLACE, Rebecca, Abernathy [US/US]; US (UsOnly)
WHITE, David, Hill [US/US]; US (UsOnly)
Inventors:
LIN, Youlin; US
WALLACE, Rebecca, Abernathy; US
WHITE, David, Hill; US
Agent:
DOWNARD, Rita, E. ; Mallinckrodt Medical, Inc. 675 McDonnell Boulevard P.O. Box 5840 St. Louis, MO 63134, US
Priority Data:
616,49521.11.1990US
Title (EN) NOVEL X-RAY CONTRAST AGENTS, COMPOSITIONS AND METHODS
(FR) NOUVEAUX AGENTS DE CONTRASTE AUX RAYONS X, COMPOSITION ET PROCEDE DE PREPARATION
Abstract:
(EN) The compound N-(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl)-glycolamido]-N'-methyl-2,4,6-triiodoisophthalamide and similar such compounds may be used as x-ray contrast agents which are water-soluble, safe and in an aqueous solution are non-viscous. Methods of preparing N-(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl)-glycolamido]-N'-methyl-2,4,6-triiodoisophthalamide and the analogous compounds are provided.
(FR) Le composé N-(2,3-dihydroxypropyle)-5-[N-(2-hydroxyéthyle)-glycolamido]-N'-méthyle-2,4,6- triiodoisophthalamide et d'autres composés similaires peuvent être utilisés comme agents de contraste, lesquels sont solubles dans l'eau, sans danger et non visqueux dans une solution aqueuse. Cette invention concerne également des procédés de préparation de N-(2,3-dihydroxypropyle)-5-[N-(2-hydroxyéthyle)-glycolamido]-N'-méthyle-2,4,6-triiodoisophthalamide et les composés analogues.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0558484US5356613JPH09507210 CA2095927AU1991076891