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1. (WO1992009561) NEW AMIDE DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009561 International Application No.: PCT/JP1991/001556
Publication Date: 11.06.1992 International Filing Date: 14.11.1991
Chapter 2 Demand Filed: 11.06.1992
IPC:
C07C 233/11 (2006.01) ,C07C 235/34 (2006.01) ,C07C 235/46 (2006.01) ,C07C 323/62 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
01
having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
02
having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
11
with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
235
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02
having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
32
the carbon skeleton containing six-membered aromatic rings
34
having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
235
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
42
having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
44
with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
46
having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
323
Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50
containing thio groups and carboxyl groups bound to the same carbon skeleton
62
having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
Applicants:
FUJISAWA PHARMACEUTICAL CO., LTD. [JP/JP]; 4-7, Doshomachi 3-chome Chuo-ku Osaka-shi Osaka 541, JP (AllExceptUS)
ITOH, Yoshikuni [JP/JP]; JP (UsOnly)
YATABE, Takumi [JP/JP]; JP (UsOnly)
OHNE, Kazuhiko [JP/JP]; JP (UsOnly)
TANAKA, Hirokazu [JP/JP]; JP (UsOnly)
Inventors:
ITOH, Yoshikuni; JP
YATABE, Takumi; JP
OHNE, Kazuhiko; JP
TANAKA, Hirokazu; JP
Agent:
SEKI, Hideo; Fujisawa Pharmaceutical Co., Ltd. Osaka Factory 1-6, Kashima 2-chome Yodogawa-ku, Osaka-shi Osaka 532, JP
Priority Data:
9025509.223.11.1990GB
Title (EN) NEW AMIDE DERIVATIVES
(FR) NOUVEAUX DERIVES D'AMIDE
Abstract:
(EN) This invention relates to new amide derivatives having an inhibitory activity against acyl-CoA: cholesterol acyltransferase enzyme and represented by general formula (I), wherein R1 is ar(lower)alkyl, R2 is aryl, R3 is alkyl or alkenyl, A is a single bond, lower alkylene or lower alkenylene, and X is O, S or a single bond, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.
(FR) Cette invention concerne des nouveaux dérivés d'amide montant une activité inhibitrice de l'acyle-CoA, c'est-à-dire la cholestérol acyltransférase, et représentés par la formule générale (I) dans laquelle R1 représente un aryle ou un alkyle inférieur, R2 représente un aryle, R3 représente un alkyle ou un alcényle, A représente une liaison unique, un alcylène inférieur ou un alcénylène inférieur, et X est O, S ou une liaison unique. L'invention concerne également des procédés de préparation de ces dérivés et une composition pharmaceutique contenant lesdits dérivés.
Designated States: JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
JPH06504521