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1. (WO1992009298) THE DELAY, PREVENTION AND/OR REVERSAL OF CELL SENESCENCE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009298 International Application No.: PCT/AU1991/000541
Publication Date: 11.06.1992 International Filing Date: 22.11.1991
Chapter 2 Demand Filed: 11.05.1992
IPC:
A61K 38/04 (2006.01) ,C07K 5/068 (2006.01) ,C07K 14/00 (2006.01) ,C12N 5/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
06
Dipeptides
068
the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
Applicants:
PEPTIDE TECHNOLOGY LTD. [AU/AU]; 4-10 Inman Road Dee Why, NSW 2099, AU (AllExceptUS)
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION [AU/AU]; Limestone Avenue Campbell, ACT 2601, AU (AllExceptUS)
GRIGG, Geoffrey, Walter [AU/AU]; AU (UsOnly)
HOLLIDAY, Robin [GB/AU]; AU (UsOnly)
McFARLAND, Gail, Annette [AU/AU]; AU (UsOnly)
Inventors:
GRIGG, Geoffrey, Walter; AU
HOLLIDAY, Robin; AU
McFARLAND, Gail, Annette; AU
Agent:
F.B. RICE & CO.; P.O. Box 117 28a Montague Street Balmain, NSW 2041, AU
Priority Data:
PK 352423.11.1990AU
Title (EN) THE DELAY, PREVENTION AND/OR REVERSAL OF CELL SENESCENCE
(FR) RETARDEMENT, PREVENTION ET/OU RENVERSEMENT DE LA SENESCENCE DE CELLULES
Abstract:
(EN) The present invention provides a method for the delay, prevention and/or reversal of cell senescence. The method of the present invention comprises administering to the cells a composition including a compound having chemical properties similar to carnosine, the active compound being present in a concentration of greater than 10mM. In preferred forms of the invention the compound is carnosine or homocarnosine and the cells are preferably human fibroblast cells. The invention also provides an improved cell culture medium which includes carnosine or a carnosine like compound.
(FR) Procédé permettant de retarder, de prévenir et/ou de renverser la sénescence de cellules. Ce procédé consiste à administrer aux cellules une composition comprenant un composé dont les propriétés chimiques sont semblables à celles de la carnosine, le composé actif étant présent à une concentration supérieure à 10 mM. Dans des modes préférés de réalisation, le composé est la carnosine ou l'homocarnosine et les cellules sont de préférence des fibroblastes humains. L'invention propose aussi un milieu de culture de cellules amélioré qui comprend de la carnosine ou un composé semblable à la carnosine.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0571390AU1991090345