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1. (WO1992009296) A PEPTIDE WHICH REGULATES WEIGHT GAIN IN MAMMALS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009296 International Application No.: PCT/US1991/008497
Publication Date: 11.06.1992 International Filing Date: 20.11.1991
Chapter 2 Demand Filed: 29.05.1992
IPC:
A61K 38/00 (2006.01) ,C07K 7/08 (2006.01) ,C07K 14/80 (2006.01) ,C07K 16/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
08
having 12 to 20 amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
795
Porphyrin- or corrin-ring-containing peptides
80
Cytochromes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
Applicants:
GEORGETOWN UNIVERSITY [US/US]; Ryan Administration Building 37th & O Streets, N.W. Washington, DC 20057, US
Inventors:
FLEMING, Patrick, J.; US
KENT, Ute, M.; US
Agent:
BEAUMONT, William, E. ; Oblon, Spivak, McClelland, Maier & Neustadt Fourth Floor 1755 South Jefferson Davis Highway Arlington, VA 22202, US
GNUSE, Robert, F.; Oblon, Spivak, McClelland, Maier & Neustadt Fourth Floor - 1755 South Jefferson Davis Highway Arlington, VA 22202, US
Priority Data:
616,91021.11.1990US
Title (EN) A PEPTIDE WHICH REGULATES WEIGHT GAIN IN MAMMALS
(FR) PEPTIDE DE REGULATION DU GAIN PONDERAL CHEZ LES MAMMIFERES
Abstract:
(EN) A peptide for regulating weight gain in mammals having formula: $g(abgdehulmprs), wherein at least six of the amino acid residues are as defined and in the sequential positions specified in the sequence: CHHRKKGYADLY, wherein C is cysteine, H is histidine, R is arginine, K is lysine, G is glycine, Y is tyrosine, A is alanine, D is aspartic acid, and L is leucine; and the remaining amino acids are each independently glycine, alanine, valine, leucine, isoleucine, serine, threonine, cysteine, methionine, aspartic acid, glutamic acid, asparagine, glutamine, lysine, hydroxy lysine, histidine, arginine, phenylalanine, tyrosine, tryptophan, proline or hydroxyproline.
(FR) L'invention se rapporte à un peptide qui permet de réguler le gain pondéral chez les mammifères et qui est représenté par la formule: $g(abgdehulmprs), dans laquelle au moins 6 des restes d'acides aminés définis ci-dessous se trouvent dans les positions séquentielles spécifiées dans la séquence: CHHRKKGYADLY, où C représente la cystéine, H représente l'histidine, R représente l'arginine, K représente la lysine, G représente le glycocolle, Y représente la tyrosine, A représente l'alalanine, D représente l'acide aspartique et L représente la leucine; et les acides aminés restants sont constitués chacun séparément par le glycocolle, l'alanine, la valine, la leucine, l'isoleucine, la sérine, la tréonine, la cystéine, la cystine, la méthionine, l'acide aspartique, l'acide glutamique, l'asparagine, la glutamine, la lysine, l'hydroxylysine, l'histidine, l'arginine, la phénylalanine, la tyrosine, le tryptophane, la proline ou l'hydroxyproline.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1991090948