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1. (WO1992009282) TREATMENT FOR TISSUE ULCERATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009282 International Application No.: PCT/US1991/008721
Publication Date: 11.06.1992 International Filing Date: 21.11.1991
Chapter 2 Demand Filed: 04.06.1992
IPC:
A61K 31/405 (2006.01) ,A61K 38/00 (2006.01) ,C07C 271/02 (2006.01) ,C07D 209/26 (2006.01) ,C07K 5/078 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
405
Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
271
Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
02
Carbamic acids; Salts of carbamic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
10
with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
18
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
26
with an acyl radical attached to the ring nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
06
Dipeptides
078
the first amino acid being heterocyclic, e.g. Pro, His, Trp
Applicants:
THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. [US/US]; 1 Progress Boulevard Alachua, FL 32615, US
GALARDY, Richard, E. [US/US]; US
GROBELNY, Damian [PL/AU]; AU
Inventors:
GALARDY, Richard, E.; US
GROBELNY, Damian; AU
SCHULTZ, Gregory; US
Agent:
MURASHIGE, Kate, H.; Morrison & Foerster 545 Middlefield Road Suite 200 Menlo Park, CA 94025, US
Priority Data:
616,02121.11.1990US
Title (EN) TREATMENT FOR TISSUE ULCERATION
(FR) TRAITEMENT CONTRE LES ULCERATIONS TISSULAIRES
Abstract:
(EN) Compounds of formulae (1) or (2) wherein R1 is H and R2 is alkyl (3-8C) or wherein R1 and R2 taken together are -(CH2)n- wherein n = 3-5; R3 is H or alkyl (1-4C); R4 is a substituted or unsubstituted fused or conjugated bicycloaryl methylene; X is OR5 or NHR5, wherein R5 is H or substituted or unsubstituted alkyl (1-12C), aryl (6-12C), aryl alkyl (6-16C); or X is an amino acid residue or amide thereof; or X is the residue of a cyclic amine or heterocyclic amine are useful for treating or preventing ulceration of tissue, especially cornea.
(FR) Les composés définis par les formules (1) ou (2) sont utiles dans le traitement ou la prévention des ulcérations tissulaires, notamment de la cornée. Dans les formules, R1 représente H et R2 représente alkyle (C3-8), ou R1 et R2 pris ensemble représentent -(CH2)n-, où n est compris entre 3 et 5; R3 représente H ou alkyle (C1-4); R4 représente un méthylène de bicycloaryle fusionné ou conjugué, substitué ou non substitué; X représente OR5 ou NHR5, où R5 représente H ou alkyle (C1-12) substitué ou non substitué, aryle (C6-12), arylalkyle (C6-16); ou X est un reste d'acide aminé ou un amide de ce dernier; ou bien X est le reste d'une amine cyclique ou d'une amine hétérocyclique.
Designated States: AT, AU, BB, BG, BR, CA, CH, CS, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MC, MG, MN, MW, NL, NO, PL, RO, SD, SE, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO19931803EP0558681JPH05508164CA2096223AU1991091351