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1. (WO1992009279) 2-ARYLTHIAZOLE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009279 International Application No.: PCT/JP1991/001670
Publication Date: 11.06.1992 International Filing Date: 29.11.1991
IPC:
A61K 31/425 (2006.01) ,A61K 31/44 (2006.01) ,A61K 31/445 (2006.01) ,A61K 31/495 (2006.01) ,A61K 31/535 (2006.01) ,C07D 277/56 (2006.01) ,C07D 417/04 (2006.01) ,C07D 417/06 (2006.01) ,C07D 417/10 (2006.01) ,C07D 417/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
32
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
56
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
TEIJIN LIMITED [JP/JP]; 6-7, Minamihommachi 1-chome Chuo-ku Osaka-shi Osaka 541, JP (AllExceptUS)
KONDO, Shiro [JP/JP]; JP (UsOnly)
FUKUSHIMA, Hisashi [JP/JP]; JP (UsOnly)
HASEGAWA, Masaichi [JP/JP]; JP (UsOnly)
TSUCHIMOTO, Masahiro [JP/JP]; JP (UsOnly)
NAGATA, Ikuo [JP/JP]; JP (UsOnly)
OSADA, Yoshio [JP/JP]; JP (UsOnly)
KOMORIYA, Keiji [JP/JP]; JP (UsOnly)
YAMAGUCHI, Hisao [JP/JP]; JP (UsOnly)
Inventors:
KONDO, Shiro; JP
FUKUSHIMA, Hisashi; JP
HASEGAWA, Masaichi; JP
TSUCHIMOTO, Masahiro; JP
NAGATA, Ikuo; JP
OSADA, Yoshio; JP
KOMORIYA, Keiji; JP
YAMAGUCHI, Hisao; JP
Agent:
AOKI, Akira ; A. Aoki & Associates Seiko Toranomon Bldg. 8-10, Toranomon 1-chome Minato-ku Tokyo 105, JP
Priority Data:
2/33014730.11.1990JP
3/21658602.08.1991JP
Title (EN) 2-ARYLTHIAZOLE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
(FR) DERIVE DE 2-ARYLTHIAZOLE ET COMPOSITION PHARMACEUTIQUE CONTENANT CE DERIVE
Abstract:
(EN) A pharmaceutical composition for treating gout, hyperuricemia and so forth, which contains an efficacious compound of a new category, i.e., a 2-arylthiazole derivative represented by general formula (I), wherein Ar represents (un)substituted pyridyl, thienyl, furyl, naphthyl or phenyl; X represents hydrogen, alkyl or optionally protected carboxyl; and Y represents hydrogen, alkyl, or optionally protected hydroxy or carbonyl. The invention also provides novel 2-arylthiazole derivatives included in these derivatives and pharmaceutically acceptable salts thereof.
(FR) Composition pharmaceutique permettant de traiter la goutte, l'hyperuricémie etc., contenant un composé efficace d'une nouvelle catégorie par exemple un dérivé de 2-arylthiazole représenté par la formule générale (I) dans laquelle Ar représente pyridile, thiényle, furyle, naphtyle ou phényle (non)substitués; X représente hydrogène, alkyle ou carboxyle éventuellement protégé; et Y représente hydrogène, alkyle ou hydroxy ou carbonyle éventuellement protégé. L'invention concerne également de nouveaux dérivés de 2-arylthiazole inclus dans ces dérivés et leurs sels pharmaceutiquement acceptables.
Designated States: AU, CA, HU, JP, KR, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, IT, NL, SE)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
EP0513379US5614520CA2073981KR1019927003052AU1991089522