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1. (WO1992009203) TNF INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009203 International Application No.: PCT/US1991/008734
Publication Date: 11.06.1992 International Filing Date: 20.11.1991
Chapter 2 Demand Filed: 19.06.1992
IPC:
A61K 31/52 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
Applicants:
SMITHKLINE BEECHAM CORPORATION [US/US]; 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406, US (AllExceptUS)
ESSER, Klaus, Max [US/US]; US (UsOnly)
Inventors:
ESSER, Klaus, Max; US
Agent:
DINNER, Dara, L. ; SmithKline Beecham Corporation Corporate Intellectual Property, UW2220 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406-0939, US
Priority Data:
616,47921.11.1990US
Title (EN) TNF INHIBITORS
(FR) INHIBITEURS DU FACTEUR NECROTIQUE TUMORAL (TNF)
Abstract:
(EN) Derivatives of 8-substituted xanthines are described which inhibit the production of TNF and are useful in the treatment of disease states mediated or exacerbated by TNF production.
(FR) Dérivés de xanthines substituées en 8, inhibant la production de TNF et utiles dans le traitement d'états pathologiques provoqués ou aggravés par la production de TNF.
Designated States: AU, CA, HU, JP, KR, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXPA/a/1991/002173IL100088EP0558659JP3204971JPH06506192CA2096623
KR1019937002896AU1991091159