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1. (WO1992009200) NOVEL POLYPEPTIDES FOR PROMOTING CELL ATTACHMENT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/009200 International Application No.: PCT/US1991/009029
Publication Date: 11.06.1992 International Filing Date: 03.12.1991
Chapter 2 Demand Filed: 29.06.1992
IPC:
A61K 38/00 (2006.01) ,A61L 27/22 (2006.01) ,C07K 14/75 (2006.01) ,C07K 14/78 (2006.01) ,C07K 16/18 (2006.01) ,C12N 5/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
22
Polypeptides or derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
745
Blood coagulation or fibrinolysis factors
75
Fibrinogen
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
78
Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
Applicants:
THE SCRIPPS RESEARCH INSTITUTE [US/US]; 10666 North Torrey Pines Road La Jolla, CA 92037, US
Inventors:
GINSBERG, Mark, H.; US
PLOW, Edward, F.; US
BOWDITCH, Ronald; US
Agent:
FITTING, Thomas; The Scripps Research Institute 10666 North Torrey Pines Road La Jolla, CA 92037 , US
Priority Data:
620,66803.12.1990US
725,60003.07.1991US
803,62327.11.1991US
Title (EN) NOVEL POLYPEPTIDES FOR PROMOTING CELL ATTACHMENT
(FR) NOUVEAUX POLYPEPTIDES POUR FAVORISER LA FIXATION CELLULAIRE
Abstract:
(EN) Novel polypeptides derived from human fibronectin are described which bind to integrin receptors expressed by cells. The receptor binding site of human fibronectin begins at amino acid residue (1394) and ends at residue (1400) of fibronectin. The polypeptides facilitate attachment of cells to substrates either alone or in conjunction with RGD-containing peptides. Vectors, fusion proteins and antibodies are also described. Methods for promoting cell attachment and for inhibiting cell adhesion are also described.
(FR) Sont décrits de nouveaux polypeptides dérivés de la fibronectine humaine, qui se lient à des récepteurs type intégrines exprimés par les cellules. Le site de fixation aux récepteurs de la fibronectine humaine commence au résidu d'aminoacide (1394) et se termine au résidu (1400) de la fibronectine. Ces polypeptides facilitent la fixation des cellules sur des substrats soit seuls soit conjointement avec des peptides contenant des RGD. Sont également décrits des vecteurs, des protéines de fusion et des anticorps. Sont par ailleurs décrits des procédés pour favoriser la fixation cellulaire et pour inhiber l'adhérence cellulaire.
Designated States: AU, CA, FI, JP, NO
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1991091659