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1. (WO1992003453) ANTIVIRAL AGENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1992/003453    International Application No.:    PCT/JP1991/001122
Publication Date: 05.03.1992 International Filing Date: 23.08.1991
A61K 31/70 (2006.01), C07H 3/06 (2006.01), C07H 15/04 (2006.01), C08B 37/00 (2006.01)
Applicants: DAINIPPON INK & CHEMICALS, INC. [JP/JP]; 35-58, Sakashita 3-chome, Itabashi-ku, Tokyo 174 (JP) (For All Designated States Except US).
SHOJI, Tadao [JP/JP]; (JP) (For US Only).
TAKAHASHI, Nahoko [JP/JP]; (JP) (For US Only).
IKUSHIMA, Naoya [JP/JP]; (JP) (For US Only).
KATSURAYA, Kaname [JP/JP]; (JP) (For US Only).
URYU, Toshiyuki [JP/JP]; (JP) (For US Only).
YOSHIDA, Takashi [JP/JP]; (JP) (For US Only).
NISHIHASHI, Hideji [JP/JP]; (JP) (For US Only).
YAMAMOTO, Naoki [JP/JP]; (JP) (For US Only).
NAKASHIMA, Hideki [JP/JP]; (JP) (For US Only).
SHIGETA, Shiro [JP/JP]; (JP) (For US Only)
Inventors: SHOJI, Tadao; (JP).
TAKAHASHI, Nahoko; (JP).
IKUSHIMA, Naoya; (JP).
KATSURAYA, Kaname; (JP).
URYU, Toshiyuki; (JP).
YOSHIDA, Takashi; (JP).
YAMAMOTO, Naoki; (JP).
NAKASHIMA, Hideki; (JP).
SHIGETA, Shiro; (JP)
Agent: SHIGA, Masatake; 6th Floor, Tokyoekimae Bldg., 1-5, Yaesu 2-chome, Chuo-ku, Tokyo 104 (JP)
Priority Data:
2/222187 23.08.1990 JP
2/228306 31.08.1990 JP
2/228307 31.08.1990 JP
2/235649 07.09.1990 JP
2/335713 30.11.1990 JP
3/99050 30.04.1991 JP
3/211833 23.08.1991 JP
Abstract: front page image
(EN)A sulfated alkyl oligosaccharide prepared by substituting the hydroxyl group at the 1-position of the terminal sugar of an oligosaccharide with an alkyl group and sulfating at least 14.3 % of the remaining hydroxyl groups of the sugar moiety; a physiologically acceptable salt thereof; and an antiviral agent containing the same as the active ingredient. This agent has a significantly reduced toxicity and an antiviral activity against a wide variety of DNA and RNA viruses irrespectively of whether the virus has an envelope or not and a particularly excellent antiviral activity against AIDS virus.
(FR)Est décrit un oligosaccharide d'alkyle sulfaté préparé par substitution du groupe hydroxyle à la position 1 du sucre terminal d'un oligosaccharide avec un groupe alkyle et sulfatation d'au moins 14,3 % des groupes hydroxyles restants de la fraction sucre; un sel physiologiquement tolérable de celui-ci; et un agent antiviral le renfermant comme principe actif. Cet agent présente une toxicité notablement réduite et une activité antivirale contre une grande variété de virus à ADN et à ARN, que le virus ait une enveloppe ou non, et une activité antivirale particulièrment excellente contre le virus du SIDA.
Designated States: AU, CA, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)