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1. (WO1992003443) ANTIBACTERIAL PENEM COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1992/003443    International Application No.:    PCT/JP1991/001099
Publication Date: 05.03.1992 International Filing Date: 16.08.1991
Chapter 2 Demand Filed:    11.02.1992    
IPC:
C07D 499/88 (2006.01)
Applicants: SUNTORY LIMITED [JP/JP]; 1-40, Dojihama 2-chome, Kita-ku, Osaka-shi, Osaka 530 (JP) (For All Designated States Except US).
IWATA, Hiromitsu [JP/JP]; (JP) (For US Only).
NATAKSUKA, Takashi [JP/JP]; (JP) (For US Only).
TANAKA, Rie [JP/JP]; (JP) (For US Only).
ISHIGURO, Masaji [JP/JP]; (JP) (For US Only)
Inventors: IWATA, Hiromitsu; (JP).
NATAKSUKA, Takashi; (JP).
TANAKA, Rie; (JP).
ISHIGURO, Masaji; (JP)
Agent: ONO, Nobuo; Fujii Bldg. 7F, 3-15, KandaSakuma-cho, Chiyoda-ku, Tokyo 101 (JP)
Priority Data:
2/217053 20.08.1990 JP
Title (EN) ANTIBACTERIAL PENEM COMPOUNDS
(FR) COMPOSES ANTIBACTERIENS DE PENEM
Abstract: front page image
(EN)Antibiotic penem coumpounds are represented by formula (I), wherein R represents a physiologically-hydrolyzable, ester-forming group. The physiologically hydrolyzable, ester-forming group useful in the penem compound of the present invention means a group which can be removed easily by $i(in vivo) hydrolysis, such as an acetyloxymethyl, 1-(acetyloxy)ethyl, pivaloyloxymethyl, 1-(ethoxycarbonyloxy)ethyl, 1-(isopropyloxycarbonyloxy)-ethyl, 1-(cyclohexyloxycarbonyloxy)ethyl or 3-phthalidyl group. Antibiotic compositions for oral administration are also described.
(FR)Composés antibiotiques de penem répondant à la formule (I), dans laquelle R représente un groupe hydrolysable par voie physiologique, à formation d'esters et utile dans le composé de penem. Ce groupe est un groupe facile à enlever par hydrolyse $i(in vivo), par exemple un groupe acétyloxyméthyle, 1-(acétyloxy)éthyle, pivaloyloxyméthyle, 1-(éthoxycarbonyloxy)éthyle, 1-(isopropyloxycarbonyloxy)éthyle, 1-(cyclohexy oxycarbonyloxy)éthyle ou 3-phtalidyle. On décrit également des compositions antibiotiques buvables.
Designated States: CA, FI, JP, KR, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE).
Publication Language: English (EN)
Filing Language: English (EN)