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Machine translation
1. (WO1992003429) RENIN INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1992/003429    International Application No.:    PCT/US1991/005524
Publication Date: 05.03.1992 International Filing Date: 02.08.1991
Chapter 2 Demand Filed:    23.01.1992    
IPC:
C07D 211/46 (2006.01), C07D 401/12 (2006.01), C07D 405/12 (2006.01), C07D 413/12 (2006.01), C07D 451/06 (2006.01), C07D 451/14 (2006.01)
Applicants: ABBOTT LABORATORIES [US/US]; Chad 0377/AP6D-2, One Abbott Park Road, Abbott Park, IL 60064-3500 (US)
Inventors: BAKER, William, R.; (US).
BOYD, Steven, A.; (US).
FUNG, Anthony, K., L.; (US).
STEIN, Herman, H.; (US).
DENISSEN, Jon, F.; (US).
HUTCHINS, Charles, W.; (US).
ROSENBERG, Saul, H.; (US)
Agent: GORMAN, Edward, H., Jr.; Abbott Laboratories, Chad 0377/AP6D-2, One Abbott Park Road, Abbott Park, IL 60064-3500 (US).
CROWLEY, Steven, R.; Abbott Laboratories, Chad 0377/AP6D-2, One Abbott Park Road, Abbott Park, IL 60064-3500 (US)
Priority Data:
568,557 15.08.1990 US
680,811 09.04.1991 US
Title (EN) RENIN INHIBITORS
(FR) INHIBITEURS DE LA RENINE
Abstract: front page image
(EN)A renin inhibiting compound of formula (I), wherein X is O, NH or S and G is a mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof; with the proviso that the compound is not N-(3-(4-Morpholino)propyl)-5(S)-(2(S)-(1(S)-(4-(methoxymethoxy)piperidin-1-yl)carbonyl-2-phenyl)ethoxyhexanamido)-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanamide.
(FR)Composé inhibant la rénine, de la formule (I), dans laquelle X représente O, NH ou S et G représentent un mime du site de clivage Leu-Val d'angiotensinogène; ou un sel un ester ou un promédicament pharmaceutiquement acceptable dudit composé; à condition que le composé ne soit pas N-(3-(4-morpholino)propyl)-5(S)-(2(S)-(1(S)-(4-méthoxyméthoxy)pipéridine-1-yl)carbonyl-2-phényl)éthoxyhéxanamido)-6-cyclohéxyl-4(S)-hydroxy-2(S)-isopropylhéxanamide.
Designated States: AU, CA, JP, KR.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE).
Publication Language: English (EN)
Filing Language: English (EN)