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Machine translation
1. (WO1992003150) CELL DENSITY SIGNAL MOLECULE ISOLATED FROM EMBRYONIC TENDON CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1992/003150    International Application No.:    PCT/US1991/005941
Publication Date: 05.03.1992 International Filing Date: 20.08.1991
Chapter 2 Demand Filed:    11.03.1992    
IPC:
A61K 38/00 (2006.01), C07K 14/475 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 300 Lakeside Drive, 22nd Floor, Oakland, CA 94612-6639 (US)
Inventors: SCHWARZ, Richard, I.; (US)
Agent: BENZ, William, H.; Morrison & Foerster, 545 Middlefield Road, Suite 200, Menlo Park, CA 94025 (US)
Priority Data:
570,422 21.08.1990 US
Title (EN) CELL DENSITY SIGNAL MOLECULE ISOLATED FROM EMBRYONIC TENDON CELLS
(FR) MOLECULE PORTANT LE SIGNAL DE LA DENSITE DES CELLULES, ISOLEE A PARTIR DE CELLULES EMBRYONNAIRES DE TENDON
Abstract: front page image
(EN)Disclosed herein is a novel proteinaceous cell density signal molecule (CDS), which is secreted by fibroblastic cells in culture, preferably tendon cells, and which provides a means by which the cells self-regulate their proliferation and the expression of differentiated function. CDS, and the antibodies which recognize them, are important for the development of diagnostics and treatments for injuries and diseases involving connective tissues, particularly tendon. Also disclosed are methods of production and use.
(FR)L'invention concerne une nouvelle molécule protéique portant le signal de la densité des cellules (SDL), molécule qui est sécrétée par des cellules fibroblastiques de culture, de préférence des cellules de tendon, et qui fournit aux cellules un moyen d'autorégulation de leur prolifération et l'expression d'une fonction différenciée. Ces nouvelles molécules et les anticorps qui les reconnaissent sont importantes pour l'évolution du diagnostic et des traitements de blessures et de maladies touchant des tissus conjonctifs, en particulier les tendons. L'invention concerne également des procédés de production et d'utilisation de ces nouvelles molécules.
Designated States: AU, FI, HU, KR, NO.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE).
Publication Language: English (EN)
Filing Language: English (EN)