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1. (WO1992003127) COMPOSITIONS AND METHODS FOR TREATING HIV INFECTIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1992/003127    International Application No.:    PCT/US1991/005919
Publication Date: 05.03.1992 International Filing Date: 15.08.1991
Chapter 2 Demand Filed:    13.03.1992    
IPC:
A61K 31/00 (2006.01)
Applicants: RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK [US/US]; P.O. Box 9, Albany, NY 12201-0009 (US) (For All Designated States Except US).
BARDOS, Thomas, J. [US/US]; (US) (For US Only).
HO, Yau-Kwan [US/US]; (US) (For US Only).
ARADI, Janos [HU/HU]; (HU) (For US Only).
SCHINAZI, Raymond, F. [US/US]; (US) (For US Only)
Inventors: BARDOS, Thomas, J.; (US).
HO, Yau-Kwan; (US).
ARADI, Janos; (HU).
SCHINAZI, Raymond, F.; (US)
Agent: COLEMAN, Henry, D.; Coleman & Sudol, 71 Broadway, Suite 1201, New York, NY 10006 (US)
Priority Data:
568,131 16.08.1990 US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING HIV INFECTIONS
(FR) COMPOSITIONS ET PROCEDES POUR LE TRAITEMENT DES INFECTIONS PAR LE VIH
Abstract: front page image
(EN)The present invention relates to a novel therapeutic method for treating HIV infections comprising administering to a patient suffering from an HIV infection an effective amount of a thiol-containing composition selected from among 5-thiolated oligonucleotides and 5-thiolated polynucleotides. These compositions have shown surprising activity against HIV-I infections $i(in vivo) (HIV infected human T-lymphocytes) indicating that the 5-thiolated poly- and oligo- nucleotide compositions are therapeutically effective agents for inhibiting HIV-I infections and for treating AIDS.
(FR)L'invention se rapporte à un nouveau procédé thérapeutique de traitement des infections par le VIH, qui consiste à administrer à un patient affecté par le VIH une quantité efficace d'une composition contenant du thiol choisi parmi des oligonucléotides thiolés en position 5 et des polynucléotides thiolés en position 5. Ces compositions se sont révélées déployer une activité surprenante contre les infections par le VIH-I $i(in vivo) (lymphocytes T humains affectés par le VIH), ce qui indique que les compositions de polynucléotides et d'oligonucléotides thiolés en position 5 constituent des agents thérapeutiques efficaces d'inhibition des infections par le VIH-I et le traitement du SIDA.
Designated States: AT, AU, BB, BG, BR, CA, CH, CS, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MC, MG, MN, MW, NL, NO, PL, RO, SD, SE, SU, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)