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1. (WO1992000979) ANTIVIRAL TETRAHYDROIMIDAZO[1,4]BENZODIAZEPIN-2-(THIO)ONES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1992/000979    International Application No.:    PCT/EP1991/001224
Publication Date: 23.01.1992 International Filing Date: 28.06.1991
Chapter 2 Demand Filed:    09.01.1992    
IPC:
C07D 487/06 (2006.01)
Applicants: JANSSEN PHARMACEUTICA N.V. [BE/BE]; Turnhoutseweg 30, B-2340 Beerse (BE)
Inventors: KUKLA, Michael, Joseph; (US).
BRESLIN, Henry, Joseph; (US).
RAEYMAEKERS, Alfons, Herman, Margaretha; (BE).
VAN GELDER, Josephus, Ludovicus, Hubertus; (BE).
JANSSEN, Paul, Adriaan, Jan; (BE)
Priority Data:
549,349 06.07.1990 US
Title (EN) ANTIVIRAL TETRAHYDROIMIDAZO[1,4]BENZODIAZEPIN-2-(THIO)ONES
(FR) TETRAHYDROIMIDAZO[1,4]BENZODIAZEPINE-2-(THIO)ONES ANTIVIRALES
Abstract: front page image
(EN)Novel tetrahydroimidazo[1,4]benzodiazepin-2-(thio)ones of formula (I), the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein X is O or S; R?1¿ is a radical of formula (a-1); (a-2); (a-3) or (a-4); R?2¿ is hydrogen or C¿1-6¿alkyl; R?3¿ is hydrogen or C¿1-6?alkyl; R?4¿ and R?5¿ each independently are hydrogen, C¿1-6?alkyl, halo, cyano, nitro, trifluoromethyl, hydroxy, C¿1-6?alkyloxy, amino, mono- or di(C¿1-6?alkyl)amino, C¿1-6?alkylcarbonylamino or arylcarbonylamino, possessing antiviral activity. Compositions containing these compounds as active ingredient and methods of treating subjects suffering from viral infections by administering said compounds.
(FR)Nouveaux tétrahydroimidazo[1,4]benzodiazépine-2-(thio)ones correspondant à la formule (I), leurs sels acides d'addition acceptables sur le plan pharmaceutique et leurs formes stéréochimiquement isomères, dans laquelle: X représente O ou S; R?1¿ représente un radical de formule: (a-1), (a-2), (a-3) ou (a-4) R?2¿ représente hydrogène ou C¿1-6?alkyle; R?3¿ représente hydrogène ou C¿1-6?alkyle; R?4¿ et R?5¿ représentent indépendamment hydrogène, C¿1-6?alkyle, halo, cyano, nitro, trifluorométhyle, hydroxy, C¿1-6?alkyloxy, amino, mono- ou di(C¿1-6?alkyle)amino, C¿1-6?alkylcarbonylamino ou arylcarbonylamino ou arylcarbonylamino, possédant une efficacité antivirale. Compositions contenant lesdits composés comme constituants actifs et procédés de traitement de patients souffrant d'infections virales par administration desdits composés.
Designated States: AU, BB, BG, BR, CA, FI, HU, JP, KP, KR, LK, MC, MG, MW, NO, PL, RO, SD, SU.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)