WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO1992000958) DERIVATIVES OF ASPARTIC ACID AND GLUTAMIC ACID HAVING ANTI-CHOLECYSTOKININ ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1992/000958    International Application No.:    PCT/GB1991/001111
Publication Date: 23.01.1992 International Filing Date: 08.07.1991
Chapter 2 Demand Filed:    12.02.1992    
IPC:
C07C 311/06 (2006.01), C07C 311/19 (2006.01), C07C 311/29 (2006.01), C07D 217/06 (2006.01), C07D 307/66 (2006.01)
Applicants: JAMES BLACK FOUNDATION LIMITED [GB/GB]; 68 Half Moon Lane, Dulwich, London SE24 9JE (GB) (For All Designated States Except US).
BROUGHTON, Howard, Barff [GB/GB]; (GB) (For US Only).
KALINDJIAN, Sarkis, Barret [GB/GB]; (GB) (For US Only).
LOW, Caroline, Minli, Rachel [GB/GB]; (GB) (For US Only).
McDONALD, Iain, Mair [GB/GB]; (GB) (For US Only).
HULL, Robert, Anthony, David [GB/GB]; (GB) (For US Only).
SHANKLEY, Nigel, Paul [GB/GB]; (GB) (For US Only)
Inventors: BROUGHTON, Howard, Barff; (GB).
KALINDJIAN, Sarkis, Barret; (GB).
LOW, Caroline, Minli, Rachel; (GB).
McDONALD, Iain, Mair; (GB).
HULL, Robert, Anthony, David; (GB).
SHANKLEY, Nigel, Paul; (GB)
Agent: FISHER, Adrian, John; Carpmaels & Ransford, 43 Bloomsbury Square, London WC1A 2RA (GB)
Priority Data:
9015360.2 12.07.1990 GB
9027283.2 17.12.1990 GB
Title (EN) DERIVATIVES OF ASPARTIC ACID AND GLUTAMIC ACID HAVING ANTI-CHOLECYSTOKININ ACTIVITY
(FR) DERIVES D'ACIDE ASPARTIQUE ET D'ACIDE GLUTAMIQUE PRESENTANT UNE ACTIVITE ANTI-CHOLECYSTOKININE
Abstract: front page image
(EN)Cholecystokinin antagonists are provided having formula (I) wherein Ar is (a), (b), (c), (d), (e), (f) or (g) (wherein the aromatic moiety may be substituted or unsubstituted), or (h); R?1¿ is H, C¿1? to C¿6? alkyl, C¿1? to C¿6? alkenyl, cycloalkyl, -(CH¿2?)¿q?aryl, -(CH¿2?)¿q?(substituted aryl) or -(CH¿2?)¿q?heterocyclic, wherein q is 0 to 4; R?2¿ is H, methyl or ethyl; T is carboxyl, -CONR?5¿R?6¿ (wherein R?5¿ and R?6¿ are independently H or C¿1? to C¿4? alkyl) or tetrazolyl; n is 0 to 3, and Q is (i) or (j) wherein X is C¿1? to C¿4? alkyl, C¿1? to C¿4? alkoxy, C¿1? to C¿4? thioalkoxy, carboxy, C¿1? to C¿4? carboalkoxy, nitro, trihalomethyl, hydroxy, -NR?7¿R?8¿ (wherein R?7¿ and R?8¿ are independently H or C¿1? to C¿4? alkyl), C¿1? to C¿4? alkylaryl, C¿1? to C¿4? alkyl(substituted aryl) or halo; m is 1 to 3; p is 0 to 3; and R?3¿ is H, C¿1? to C¿5? alkyl or -(CH¿2?)¿r?R?4¿ wherein r is 0 to 4 and R?4¿ is aryl or substituted aryl; and pharmaceutically acceptable salts thereof.
(FR)On décrit des antagonistes de cholécystokinine de la formule (I) où Ar représente (a), (b), (c), (d), (e), (f) ou (g) (où la fraction aromatique peut être substituée ou non), ou R?1¿ représente H, alkyle C¿1? à C¿6?, alcényle C¿1? à C¿6?, cycloalkyle, -(CH¿2?)¿q?aryle, -(CH¿2?)¿q?(aryle substitué) ou -(CH¿2?)¿q? hétérocyclique, où q vaut de 0 à 4; R?2¿ représente H, méthyle ou éthyle; T représente carboxyle, -CONR?5¿R?6¿ (où R?5¿ et R?6¿ représentent indépendamment H ou alkyle C¿1? à C¿4?) ou tétrazolyle; n vaut de 0 à 3, et Q représente (i) ou (j) où X représente alkyle C¿1? à C¿4?, alcoxy C¿1? à C¿4?, thioalcoxy, carboxy, carboalcoxy C¿1? à C¿4?, nitro, trihalométhyle, hydroxy, -NR?7¿R?8¿ (où R?7¿ et R?8¿ représentent indépendamment H ou alkyle C¿1? à C¿4?), alkylaryle C¿1? à C¿4?, alkyle C¿1? à C¿4? (aryle substitué) ou halo; m vaut de 1 à 3; p vaut de 0 à 3; et R?3¿ représente H, alkyle C¿1? à C¿5? ou -(CH¿2?)¿r?R?4¿ où r vaut de 0 à 4, R?4¿ représente aryle ou aryle substitué. On décrit aussi des sels pharmaceutiquement acceptables de ces antagonistes.
Designated States: AT, AU, BB, BG, BR, CA, CH, CS, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MC, MG, MN, MW, NL, NO, PL, RO, SD, SE, SU, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)