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1. WO1992000387 - NEUROFIBROMATOSIS GENE

Publication Number WO/1992/000387
Publication Date 09.01.1992
International Application No. PCT/US1991/004624
International Filing Date 28.06.1991
Chapter 2 Demand Filed 10.01.1992
IPC
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12Q 1/68 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/156
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
Y10S 530/828
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
530Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
827Proteins from mammals or birds
828Cancer
Applicants
  • THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US]/[US] (AllExceptUS)
  • COLLINS, Francis, S. [US]/[US] (UsOnly)
  • WALLACE, Margaret, R. [US]/[US] (UsOnly)
  • MARCHUK, Douglas, A. [US]/[US] (UsOnly)
  • ANDERSEN, Lone, B. [DK]/[US] (UsOnly)
  • GUTMANN, David, H. [US]/[US] (UsOnly)
Inventors
  • COLLINS, Francis, S.
  • WALLACE, Margaret, R.
  • MARCHUK, Douglas, A.
  • ANDERSEN, Lone, B.
  • GUTMANN, David, H.
Agents
  • LEWAK, Anna, M.
Priority Data
547,09029.06.1990US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NEUROFIBROMATOSIS GENE
(FR) GENE DE NEUROFIBROMATOSE
Abstract
(EN) The entire coding region of the gene involved in von Recklinghausen neurofibromatosis (NF1) and a ubiquitously expressed large transcript (NF1LT) of the gene have been identified, cloned and sequenced. With the identification of the NF1 gene and its gene product, nucleic acid probes and antibodies raised to the gene product can be used in a variety of hybridization and immunological assays to screen for NF1 and detect it in its early stages. Conventional and gene therapies can also be developed to treat those afflicted with the disease.
(FR) On a identifié, cloné et séquencé la totalité de la région codante du gène impliqué dans la neurofibromatose de von Recklinghausen (NF1) ainsi qu'un grand transcript (NF1LT) exprimé de manière ubiquiste du gène. Grâce à l'identification du gène de NF1 et de son produit génétique, on peut utiliser des sondes d'acide nucléique ainsi que des anticorps développés contre le produit génétique dans une variété de dosage d'hybridation et immunologique, afin de procéder à la recherche du NF1 et de le détecter dans ses premières manifestations. On peut également développer des thérapies classiques et génétiques afin de traiter les personnes atteintes de la maladie.
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