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1. (WO1991018099) TARGET-SPECIFIC, CYTOTOXIC, RECOMBINANT PSEUDOMONAS EXOTOXIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/018099 International Application No.: PCT/US1991/003121
Publication Date: 28.11.1991 International Filing Date: 10.05.1991
Chapter 2 Demand Filed: 10.05.1991
IPC:
A61K 38/00 (2006.01) ,C07K 14/21 (2006.01) ,C07K 14/495 (2006.01) ,C07K 14/73 (2006.01) ,C07K 16/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
21
from Pseudomonadaceae (F)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
495
Transforming growth factor (TGF)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
725
T-cell receptors
73
CD4
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants:
THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, U.S. DEPARTMENT OF COMMERCE [US/US]; 5285 Port Royal Road Springfield, VA 22161, US
Inventors:
PASTAN, Ira; US
CHAUDHARY, Vijay, K.; US
FITZGERALD, David; US
Agent:
HOLMAN, John, Clarke ; Fleit, Jacobson, Cohn, Price, Holman & Stern The Jenifer Building 400 Seventh Street, N.W. Washington, DC 20004, US
Priority Data:
522,56314.05.1990US
Title (EN) TARGET-SPECIFIC, CYTOTOXIC, RECOMBINANT PSEUDOMONAS EXOTOXIN
(FR) EXOTOXINE RECOMBINEE DE PSEUDOMONAS CYTOTOXIQUE, SPECIFIQUE DE CIBLES
Abstract:
(EN) A target-specific, cytotoxic, recombinant $i(Pseudomonas) exotoxin is described. Such toxins are made by inserting specific recognition molecules at specific cloning sites in at least domain III near the carboxyl terminus of the PE molecule. Various modifications of the carboxyl terminus of the PE molecule to increase cytotoxicity are set forth. Multifunctional, recombinant, cytotoxic fusion proteins containing at least two different recognition molecules are provided for killing cells expressing receptors to which the recognition molecules bind with specificity. Methods for producing novel recombinant PE molecules with specific properties are described.
(FR) Exotoxine recombinée de $i(Pseudomonas) cytotoxique, spécifique de cibles. Lesdites toxines sont obtenues par insertion de molécules de reconnaissance spécifique dans des sites de clonage spécifique dans au moins le domaine III, près de la terminaison carboxyle de la molécule PE. L'invention concerne diverses modifications de la terminaison carboxyle de la molécule PE afin d'accroître la cytotoxicité. L'invention concerne également des protéines de fusion multifonctionnelles, recombinées, cytotoxiques contenant au moins deux molécules de reconnaissance différentes destinées à tuer les cellules exprimant des récepteurs auxquels les molécules de reconnaissance se lient par spécificité. En outre, l'invention concerne des procédés de production de nouvelles molécules PE recombinées présentant des propriétés spécifiques.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0597844CA2082824AU1991079868