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1. (WO1991018089) ASSOCIATION BETWEEN A HUMAN IMMUNODEFICIENCY VIRUS-RELATED RETROVIRUS AND SJOGREN'S SYNDROME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/018089 International Application No.: PCT/US1991/003545
Publication Date: 28.11.1991 International Filing Date: 20.05.1991
Chapter 2 Demand Filed: 19.12.1991
IPC:
A61K 31/7072 (2006.01) ,A61K 31/7076 (2006.01) ,A61K 39/00 (2006.01) ,C07K 14/15 (2006.01) ,C12N 7/00 (2006.01) ,C12N 7/02 (2006.01) ,G01N 33/564 (2006.01) ,G01N 33/569 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706
containing six-membered rings with nitrogen as a ring hetero atom
7064
containing condensed or non-condensed pyrimidines
7068
having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
7072
having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706
containing six-membered rings with nitrogen as a ring hetero atom
7064
containing condensed or non-condensed pyrimidines
7076
containing purines, e.g. adenosine, adenylic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
15
Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7
Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7
Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
02
Recovery or purification
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
564
for pre-existing immune complex or autoimmune disease
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
Applicants:
GARRY, Robert, F., Jr. [US/US]; US
FERMIN, Cesar, D. [US/US]; US
ALEXANDER, Steve, S., Jr. [US/US]; US
Inventors:
GARRY, Robert, F., Jr.; US
FERMIN, Cesar, D.; US
ALEXANDER, Steve, S., Jr.; US
Agent:
MISROCK, S., Leslie; Pennie & Edmonds 1155 Avenue of the Americas New York, NY 10036, US
Priority Data:
526,34921.05.1990US
Title (EN) ASSOCIATION BETWEEN A HUMAN IMMUNODEFICIENCY VIRUS-RELATED RETROVIRUS AND SJOGREN'S SYNDROME
(FR) ASSOCIATION ENTRE UN RETROVIRUS APPARENTE AU VIRUS D'IMMUNODEFICIENCE HUMAINE ET LE SYNDROME DE SJOGREN
Abstract:
(EN) The present invention relates to purified preparations of a novel retrovirus, to methods of diagnosis and treatment of Sjogren's syndrome, novel cell lines, and model systems for the study of autoimmune diseases and AIDS. It is based, in part, on the discovery of a novel retrovirus which is antigenically similar to human immunodeficiency virus but which appears to comprise a functionally distinct reverse transcriptase. According to the present invention, Sjogren's syndrome as well as other autoimmune diseases, may be diagnosed, and their clinical course may be monitored, by demonstrating the presence of anti-retroviral antibodies and/or measuring the levels of such antibodies. Alternatively, Sjogren's syndrome or other autoimmune diseases may be diagnosed or monitored by directly or indirectly demonstrating viral particles in the cells of a patient. Furthermore, according to the invention, Sjogren's patients who have been found to exhibit retrovirus or anti-retroviral antibodies may be treated with agents known to be useful in the treatment of retroviral diseases, including but not limited to, agents which interfere with reverse transcriptase function, such as, for example, nucleoside analogues (e.g. zidovudine or dideoxyinosine).
(FR) Préparations purifiées d'un nouveau rétrovirus, procédés de diagnostic et de traitement du syndrome de Sjögren, nouvelle lignée cellulaire, et systèmes de modèles utilisés dans l'étude de maladies auto-immunes et du SIDA. L'invention se base, en partie, sur la découverte d'un nouveau rétrovirus antigéniquement similaire au virus de l'immunodéficience humaine mais comprenant apparemment une transcriptase inverse fonctionnellement distincte. Selon l'invention, on peut diagnostiquer le syndrome de Sjögren ainsi que d'autres maladies auto-immunes et contrôler leur évolution clinique en démontrant la présence d'anticorps antirétroviraux et/ou en mesurant les niveaux desdits anticorps. Selon un autre mode de réalisation, on peut diagnostiquer ou contrôler le syndrome de Sjögren ou d'autres maladies auto-immunes en mettant en lumière directement ou indirectement des particules virales se trouvant dans les cellules d'un patient. En outre, selon l'invention on peut traiter des patients atteints du syndrome de Sjögren et présentant des anticorps antirétroviraux à l'aide d'agents dont on sait qu'ils sont utiles dans le traitement de maladies rétrovirales, comprenant de manière non exhaustives des agents perturbant la fonction transcriptase inverse, telle que, par exemple, des analogues de nucléosides (par exemple la zidovudine ou la didésoxyinosine).
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0535021JPH05506359CA2083493AU1991079592DK0535021