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1. (WO1991017973) 5H-DIBENZO(a,d)CYCLOHEPTENES AS MUSCARINIC RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017973 International Application No.: PCT/US1991/002914
Publication Date: 28.11.1991 International Filing Date: 25.04.1991
Chapter 2 Demand Filed: 25.11.1991
IPC:
C07C 211/32 (2006.01) ,C07D 211/70 (2006.01) ,C07D 295/03 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
01
having amino groups bound to acyclic carbon atoms
26
of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
31
the six-membered aromatic ring being part of a condensed ring system formed by at least three rings
32
containing dibenzocycloheptane or dibenzocycloheptene ring systems or condensed derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
68
having one double bond between ring members or between a ring member and a non-ring member
70
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
295
Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
02
containing only hydrogen and carbon atoms in addition to the ring hetero elements
027
containing only one hetero ring
03
with the ring nitrogen atoms directly attached to acyclic carbon atoms
Applicants:
MERRELL DOW PHARMACEUTICALS INC. [US/US]; 2100 E. Galbraith Road P.O. Box 156300 Cincinnati, OH 45215-6300, US (AllExceptUS)
HIBERT, Marcel [FR/FR]; FR (UsOnly)
VAN HIJFTE, Luc [BE/FR]; FR (UsOnly)
RICHARDS, Mary [FR/FR]; FR (UsOnly)
MOSER, Paul [GB/FR]; FR (UsOnly)
Inventors:
HIBERT, Marcel; FR
VAN HIJFTE, Luc; FR
RICHARDS, Mary; FR
MOSER, Paul; FR
Agent:
MOON, Carolyn, D. ; Marion Merrell Dow Inc. 2110 East Galbraith Road P.O. Box 156300 Cincinnati, OH 45215-6300, US
Priority Data:
90401332.318.05.1990EP
Title (EN) 5H-DIBENZO(a,d)CYCLOHEPTENES AS MUSCARINIC RECEPTOR ANTAGONISTS
(FR) 5H-DIBENZO(a,d)CYCLOHEPTENES UTILISES COMME ANTAGONISTES DE RECEPTEURS MUSCARINIQUES
Abstract:
(EN) This invention relates to novel derivatives of 5H-dibenzo[a,d]cycloheptenes, to the processes for their preparation, to their muscarinic receptor antagonist properties and to their end-use application for treating Parkinson's Disease, tardive dyskinesia, and motion sickness.
(FR) Nouveaux dérivés de 5H-dibenzo[a,d]cycloheptènes, leurs procédés de préparation, leurs propriétés d'antagonistes de récepteurs muscariniques ainsi que leur application d'usage final dans le traitement de la maladie de Parkinson, de dyskinésies tardives, et du mal des transports.
Designated States: AU, CA, FI, HU, JP, KR, NO, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0581767US5508280JPH05508399DE000069127549AU1991079571