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1. (WO1991017823) METHOD AND APPARATUS FOR BIOPOLYMER SYNTHESIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017823 International Application No.: PCT/US1991/002776
Publication Date: 28.11.1991 International Filing Date: 23.04.1991
Chapter 2 Demand Filed: 03.12.1991
IPC:
B01J 19/00 (2006.01) ,C07H 21/00 (2006.01) ,C07K 1/04 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
J
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19
Chemical, physical, or physico-chemical processes in general; Their relevant apparatus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
04
on carriers
Applicants:
PROTOS CORPORATION [US/US]; 4560 Horton Street Emeryville, CA 94608-2916, US
Inventors:
ZUCKERMANN, Ronald, N.; US
HEUBNER, Verena, D.; US
SANTI, Daniel, V.; US
SIANI, Michael, A.; US
Agent:
DEHLINGER & SWISS; P.O. Box 60850 Palo Alto, CA 94306, US
GOLDIN, Douglas, Michael; J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5LX, GB
Priority Data:
523,79115.05.1990US
652,19407.02.1991US
Title (EN) METHOD AND APPARATUS FOR BIOPOLYMER SYNTHESIS
(FR) PROCEDE ET APPAREIL SERVANT A SYNTHETISER DES BIOPOLYMERES
Abstract:
(EN) Method and apparatus for synthesizing biopolymers, such as polypeptides and polynucleotides. The apparatus includes plural reaction vessels in which subunit coupling to biopolymers in a particle suspension is carried out. The vessels are connected to common valving structure for use in mixing the suspension and removing suspension liquid. In one embodiment, a robotic arm in the apparatus is operable to transfer reaction solution to the reaction vessels, and to transfer particle suspensions from the reaction vessels to a mixing vessel and back to the reaction vessels. The method can be used to produce preferably equi-molar amounts of different sequence biopolymers, such as polypeptides and polynucleotides.
(FR) Procédé et appareil servant à synthétiser des biopolymères, tels que polypeptides et polynucléotides. L'appareil comporte plusieurs cuves de réaction dans lesquelles on procède au couplage de sous-unités à des biopolymères dans une suspension de particules. Les cuves sont connectées à une structure de vannes commune qui est utilisée pour le mélange de la suspension et pour l'élimination du liquide de suspension. Dans une variante, un bras robotique de l'appareil sert à transférer la solution de réaction aux cuves de réaction, et à transférer les suspensions de particules des cuves de réaction à une cuve de mélange puis de nouveau aux cuves de réaction. Le procédé peut être utilisé pour produire des quantités, de préférence équimoléculaires, de biopolymères de séquences différentes, tels que polypeptides et polynucléotides.
Designated States: CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0593460CA2082650DK0593460