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1. (WO1991017769) NOVEL METHODS FOR PRODUCING ANTIGEN-SPECIFIC, HIGH-AFFINITY HUMAN MONOCLONAL ANTIBODIES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017769 International Application No.: PCT/US1991/003406
Publication Date: 28.11.1991 International Filing Date: 21.05.1991
Chapter 2 Demand Filed: 20.12.1991
IPC:
A61K 38/00 (2006.01) ,C07K 16/00 (2006.01) ,C07K 16/18 (2006.01) ,C07K 16/42 (2006.01) ,C12N 5/16 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
42
against immunoglobulins (anti-idiotypic antibodies)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
12
Fused cells, e.g. hybridomas
16
Animal cells
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 300 Lakeside Drive, 22nd Floor Oakland, CA 94612-3550, US
Inventors:
BOERNER, Paula; US
ROYSTON, Yvor; US
Agent:
DREGER, Walter, H. ; Flehr, Hohbach, Test, Albritton & Herbert Four Embarcadero Center Suite 3400 San Francisco, CA 94111-4187, US
Priority Data:
527,20322.05.1990US
688,65419.04.1991US
Title (EN) NOVEL METHODS FOR PRODUCING ANTIGEN-SPECIFIC, HIGH-AFFINITY HUMAN MONOCLONAL ANTIBODIES
(FR) NOUVEAU PROCEDE DE PRODUCTION D'ANTICORPS MONOCLONAUX HUMAINS DE HAUTE AFFINITE SPECIFIQUE D'ANTIGENES
Abstract:
(EN) The present invention relates to advances in monoclonal antibody production, and particularly, in culturing methodology preparatory to hybridoma formation. Specifically, retention of lymphoid fragments in the culture systems results in predominantly IgG-secreting, long-lived cultures.
(FR) L'invention a trait à des progrès relatifs à la production d'anticorps monoclonaux, et notamment, à une méthodologie de culture préparatoire à la formation d'hybridomes. Spécifiquement, la rétention de fragments lymphoïdes dans des systèmes de culture a pour résultat des cultures à durée de vie prolongée secrétant essentiellement de l'IgG.
Designated States: AU, CA, FI, HU, JP, KR, NO, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI925081NO19924475EP0533841JPH05507414CA2082041KR1019930700153
AU1991081070