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1. (WO1991017755) COMPOSITIONS AND METHODS FOR MODULATING RNA ACTIVITY THROUGH MODIFICATION OF THE 5' CAP STRUCTURE OF RNA
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017755 International Application No.: PCT/US1991/003606
Publication Date: 28.11.1991 International Filing Date: 22.05.1991
Chapter 2 Demand Filed: 03.12.1991
IPC:
C07H 21/00 (2006.01) ,C07H 23/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
23
Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
Applicants:
ISIS PHARMACEUTICALS, INC. [US/US]; 2280 Faraday Avenue Carlsbad, CA 92008, US (AllExceptUS)
BAKER, Brenda, F. [US/US]; US (UsOnly)
Inventors:
BAKER, Brenda, F.; US
Agent:
CALDWELL, John, W. ; Woodcock Washburn Kurtz Mackiewicz & Norris One Liberty Place - 46th Floor Philadelphia, PA 19103, US
Priority Data:
527,59923.05.1990US
Title (EN) COMPOSITIONS AND METHODS FOR MODULATING RNA ACTIVITY THROUGH MODIFICATION OF THE 5' CAP STRUCTURE OF RNA
(FR) COMPOSITIONS ET PROCEDES SERVANT A MODULER L'ACTIVITE DE L'ARN PAR MODIFICATION DE LA STRUCTURE 5' CAP DE L'ARN
Abstract:
(EN) Methods for achieving therapeutic treatment of diseases and for regulating gene expression in biological experimental systems via modification or removal of the 5' Cap structure of targeted ribonucleic acids are disclosed. Modification or removal of the 5' Cap structure is achieved in accordance with preferred embodiments utilizing antisense compounds which are complementary to the 5' terminus of the targeted RNA and have attached to them reactive moieties explicitly designed for chemical modification of or cleavage reactions with the 5' Cap structure of RNA.
(FR) Procédés servant au traitement thérapeutique de maladies et à réguler l'expression de gènes dans des systèmes biologiques expérimentaux par modification ou élimination de la structure Cap 5' d'acides ribonucléiques ciblés. Dans les variantes préférées, la modification ou l'élimination de la structure Cap 5' est obtenue au moyen de composés non codants qui sont complémentaires de la terminaison 5' de l'acide ribonucléique ciblé et auxquels sont combinées des fractions réactives destinées spécifiquement à la modification chimique de la structure Cap 5' de l'ARN ou à des réactions de clivage avec cette même structure.
Designated States: AU, BR, CA, FI, HU, JP, KR, NO, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI925210NO19924309EP0531447CA2083377KR1019930700118AU1991080802