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1. (WO1991017748) ISOXAZOLE-4-CARBOXAMIDES AND HYDROXYALKYLIDENE-CYANOACETAMIDES, DRUGS CONTAINING THESE COMPOUNDS AND USE OF SUCH DRUGS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017748 International Application No.: PCT/EP1990/001800
Publication Date: 28.11.1991 International Filing Date: 24.10.1990
Chapter 2 Demand Filed: 21.11.1991
IPC:
A61K 31/275 (2006.01) ,A61K 31/42 (2006.01) ,C07C 255/23 (2006.01) ,C07C 317/40 (2006.01) ,C07D 213/75 (2006.01) ,C07D 231/56 (2006.01) ,C07D 235/30 (2006.01) ,C07D 239/42 (2006.01) ,C07D 277/46 (2006.01) ,C07D 277/82 (2006.01) ,C07D 317/66 (2006.01) ,C07D 413/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
275
Nitriles; Isonitriles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42
Oxazoles
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
255
Carboxylic acid nitriles
01
having cyano groups bound to acyclic carbon atoms
23
containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
317
Sulfones; Sulfoxides
26
having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
32
with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
34
having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
38
with the nitrogen atom of at least one amino group being part of any of the groups X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
40
Y being a hydrogen or a carbon atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72
Nitrogen atoms
75
Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
54
condensed with carbocyclic rings or ring systems
56
Benzopyrazoles; Hydrogenated benzopyrazoles
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
235
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02
condensed with carbocyclic rings or ring systems
04
Benzimidazoles; Hydrogenated benzimidazoles
24
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
30
Nitrogen atoms not forming part of a nitro radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32
One oxygen, sulfur or nitrogen atom
42
One nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
32
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38
Nitrogen atoms
44
Acylated amino or imino radicals
46
by carboxylic acids, or sulfur or nitrogen analogues thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
60
condensed with carbocyclic rings or ring systems
62
Benzothiazoles
68
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
82
Nitrogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
317
Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08
having the hetero atoms in positions 1 and 3
44
ortho- or peri-condensed with carbocyclic rings or ring systems
46
condensed with one six-membered ring
48
Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
62
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
66
Nitrogen atoms not forming part of a nitro radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
HOECHST AKTIENGESELLSCHAFT [DE/DE]; Postfach 80 03 20 D-6230 Frankfurt am Main 80, DE (AllExceptUS)
BARTLETT, Robert, R. [US/DE]; DE (UsOnly)
KÄMMERER, Friedrich-Johannes [DE/DE]; DE (UsOnly)
Inventors:
BARTLETT, Robert, R.; DE
KÄMMERER, Friedrich-Johannes; DE
Common
Representative:
HOECHST AKTIENGESELLSCHAFT; Zentrale Patentabteilung Postfach 80 03 20 D-6230 Frankfurt am Main 80, DE
Priority Data:
P 30 17 043.826.05.1990DE
P 40 16 178.118.05.1990DE
P 40 17 020.926.05.1990DE
Title (DE) ISOXAZOL-4-CARBONSÄUREAMIDE UND HYDROXYALKYLIDEN-CYANESSIGSÄUREAMIDE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG
(EN) ISOXAZOLE-4-CARBOXAMIDES AND HYDROXYALKYLIDENE-CYANOACETAMIDES, DRUGS CONTAINING THESE COMPOUNDS AND USE OF SUCH DRUGS
(FR) AMIDES D'ACIDE CARBOXYLIQUE-4 D'ISOXAZOL ET CYANAMIDES ACETIQUES D'HYDROXYALKYLIDENE, MEDICAMENTS CONTENANT CES COMPOSES ET LEUR APPLICATION
Abstract:
(DE) Isoxazol-4-carbonsäureamidderivate und Hydroxyalkyliden-cyanessigsäureamidderivate eignen sich zur Behandlung von Krebserkrankungen. Diese Verbindungen lassen sich nach bekannten Verfahren herstellen. Ein Teil der Verbindungen ist neu und eignet sich zusätzlich zur Behandlung von Rheumaerkrankungen.
(EN) Isoxazole-4-carboxamide derivatives and hydroxyalkylidene-cyanoacetamide derivatives are suitable for the treatment of cancer diseases. These compounds can be prepared by prior art methods. Some of them are new and are suitable, in addition, for the treatment of rheumatic diseases.
(FR) Des dérivés d'acide carboxylique-4 d'isoxazol et des dérivés de cyanamides acétiques d'hydroxyalkylidène conviennent au traitement de maladies cancéreuses. Ces composés peuvent être fabriqués selon des procédés connus. Une partie des composés est nouvelle et convient en outre au traitement de maladies rhumatismales.
Designated States: AT, AU, BB, BG, BR, CA, CH, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MC, MG, MW, NL, NO, RO, SD, SE, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
FI925211FI951697NO19924433EP0527736RU94033835RU02084223
US5494911JP2995086JPH05506425CA2083179KR1001888010000*AU1990065468