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1. (WO1991017442) PROTEIN-NUCLEIC ACID PROBES AND IMMUNOASSAYS USING SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017442 International Application No.: PCT/US1991/002925
Publication Date: 14.11.1991 International Filing Date: 06.05.1991
Chapter 2 Demand Filed: 02.12.1991
IPC:
C07H 19/06 (2006.01) ,C07H 21/00 (2006.01) ,C12Q 1/68 (2006.01) ,G01N 33/532 (2006.01) ,G01N 33/543 (2006.01) ,G01N 33/58 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
06
Pyrimidine radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
531
Production of immunochemical test materials
532
Production of labelled immunochemicals
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58
involving labelled substances
Applicants:
CHIRON CORPORATION [US/US]; 4560 Horton Street Emeryville, CA 94608, US
Inventors:
URDEA, Michael, S.; US
Agent:
CIOTTI, Thomas, E. ; Morrison & Foerster 545 Middlefield Road Suite 200 Menlo Park, CA 94025-3471, US
Priority Data:
519,21204.05.1990US
Title (EN) PROTEIN-NUCLEIC ACID PROBES AND IMMUNOASSAYS USING SAME
(FR) SONDES DE PROTEINE-ACIDE NUCLEIQUE ET DOSAGES IMMUNOLOGIQUES LES UTILISANT
Abstract:
(EN) In one aspect of this invention, various protein/nucleic acid hybrid probes are described which can be used to amplify the detectable signal in immunoassays. The protein moiety is capable of functioning either as an antibody or an antigen. The nucleic acid moiety serves as a signal amplifier. In another aspect, various methods of amplifying the detectable signal in immunoassays by use of the hybrid probes and related polynucleotide probes are disclosed.
(FR) On a mis au point diverses sondes hybrides de protéine-acide nucléique pouvant être utilisées afin d'amplifier le signal détectable dans des dosages immunologiques. La fraction protéique est capable de fonctionner soit comme un anticorps soit comme un antigène. La fraction d'acide nucléique sert d'amplificateur de signal. L'invention concerne, dans un autre aspect, divers procédés d'amplification du signal détectable dans des dosages immunologiques à l'aide des sondes hybrides et de sondes de polynucléotides apparentées.
Designated States: AT, AU, BB, BG, BR, CA, CH, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MC, MG, MW, NL, NO, PL, RO, SD, SE, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI924897NO19924226EP0528870RU02107730JP3034304JPH06506768
CA2081455KR1001716170000*AU1991077912