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1. (WO1991017428) SOLVANT MEDIATED RELAXATION ASSAY SYSTEM
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017428 International Application No.: PCT/US1991/003072
Publication Date: 14.11.1991 International Filing Date: 03.05.1991
Chapter 2 Demand Filed: 20.11.1991
IPC:
G01N 33/543 (2006.01) ,G01N 33/66 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
66
involving blood sugars, e.g. galactose
Applicants:
ADVANCED MAGNETICS INC. [US/US]; 61 Mooney Street Cambridge, MA 02138-1038, US
Inventors:
JOSEPHSON, Lee; US
MENZ, Edward, T.; US
GROMAN, Ernest, V.; US
Agent:
SUNSTEIN, Bruce, D. ; Bromberg & Sunstein 10 West Street Boston, MA 02111, US
Priority Data:
518,56703.05.1990US
Title (EN) SOLVANT MEDIATED RELAXATION ASSAY SYSTEM
(FR) SYSTEME D'ANALYSE UTILISANT LA LIBERATION DE PROTONS PAR UN SOLVANT
Abstract:
(EN) A new ligand binding assay is based upon measurements of relaxation rates of the solvent, which are obtained with a magnetic resonance (MR) spectrometer. It is termed a solvent mediated relaxation assay system (SMRAS). SMRAS is based on the observation that the enhancement of proton relaxation rates produced by a magnetic material can be modulated by the binding of various analytes to a magnetic material. Hence the relaxation rate of the solvent can be interpreted to give information on the concentration of an analyte.
(FR) L'invention se rapporte à un nouveau procédé d'analyse par liaison de ligands, qui se fonde sur les mesures des vitesses de libération de protons par un solvant, ces mesures étant obtenues au moyen d'un spectromètre à résonance magnétique (MR). Le système d'analyse ainsi produit (appelé SMRAS) se fonde sur l'observation selon laquelle l'augmentation des vitesses de libération de protons produite par un matériau magnétique peut être modulée par la liaison de divers analytes à une substance magnétique. Ainsi, la vitesse de libération des protons par le solvant peut être soumise à une interprétation destinée à fournir des informations sur la concentration d'un analyte.
Designated States: CA, JP, NO
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0527208US5254460JPH05507352CA2081894