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1. (WO1991017266) IDENTIFICATION OF NOVEL DRUGS AND REAGENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017266 International Application No.: PCT/US1991/002574
Publication Date: 14.11.1991 International Filing Date: 15.04.1991
Chapter 2 Demand Filed: 19.11.1991
IPC:
C12N 15/11 (2006.01) ,C12Q 1/02 (2006.01) ,C12Q 1/68 (2006.01) ,G01N 33/50 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants:
ISIS PHARMACEUTICALS, INC. [US/US]; 2280 Faraday Avenue Carlsbad, CA 92008, US
Inventors:
MIRABELLI, Christopher, K.; US
VICKERS, Timothy; US
ECKER, David, J.; US
Agent:
CALDWELL, John, W. ; Woodcock Washburn Kurtz Mackiewicz & Norris One Liberty Place 46th Floor Philadelphia, PA 19103, US
Priority Data:
517,24001.05.1990US
Title (EN) IDENTIFICATION OF NOVEL DRUGS AND REAGENTS
(FR) PROCEDES D'IDENTIFICATION DES NOUVEAUX MEDICAMENTS ET REACTIFS
Abstract:
(EN) Methods for identifying oligonucleotides capable of hybridizing with nucleic acid of an infectious agent are disclosed. In accordance with preferred embodiments, oligonucleotides capable of antisense interaction with RNA which is significant to a bodily state of an animal or which is contributory to a diseased state is identified. Therapeutic, diagnostic and research methods and compositions employing such oligonucleotides are provided. Prior knowledge of the sequence of nucleic acid in the infectious agent is generally not required.
(FR) Procédés d'identification d'oligonucléotides aptes à s'hybrider avec l'acide nucléique d'un agent infectieux. Selon des modes de réalisation préférés, on identifie des oligonucléotides adaptés à l'interaction non codante avec de l'ARN qui est significatif en ce qui concerne l'état physique d'un animal ou qui contribue à un état maladif. On a prévu des procédés et des compositions thérapeutiques, diagnostiques et de recherche utilisant ces oligonucléotides. Une connaissance préalable de la séquence d'acide nucléique dans l'agent infectieux n'est pas nécessaire.
Designated States: AU, BR, CA, FI, HU, JP, KR, NO
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0527941JPH05505529CA2081984AU1991079747