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1. (WO1991017260) METHOD OF IDENTIFYING COMPOUNDS USEFUL AS ANTIPARASITE DRUGS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017260 International Application No.: PCT/US1991/002767
Publication Date: 14.11.1991 International Filing Date: 25.04.1991
Chapter 2 Demand Filed: 04.11.1991
IPC:
C12N 9/04 (2006.01) ,C12N 9/12 (2006.01) ,C12N 9/88 (2006.01) ,C12Q 1/02 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02
Oxidoreductases (1.), e.g. luciferase
04
acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10
Transferases (2.)
12
transferring phosphorus containing groups, e.g. kinases (2.7)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
88
Lyases (4.)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
Applicants:
THE UPJOHN COMPANY [US/US]; 301 Henrietta Street Kalamazoo, MI 49001, US (AllExceptUS)
KLEIN, Ronald, D. [US/US]; US (UsOnly)
GREARY, Timothy, G. [US/US]; US (UsOnly)
Inventors:
KLEIN, Ronald, D.; US
GREARY, Timothy, G.; US
Agent:
DELUCA, Mark; The Upjohn Company Corporate Patents & Trademarks Kalamazoo, MI 49001, US
PERRY, Robert, E.; Gill Jennings & Every 53-64 Chancery Lane London WC2A 1HN, GB
Priority Data:
517,63302.05.1990US
Title (EN) METHOD OF IDENTIFYING COMPOUNDS USEFUL AS ANTIPARASITE DRUGS
(FR) PROCEDE D'IDENTIFICATION DE COMPOSES UTILES EN TANT QUE MEDICAMENTS ANTIPARASITES
Abstract:
(EN) A method for identifying compounds useful as antiparasitic drugs is disclosed. Deficient microorganisms are complemented with parasites' homologous metabolic enzyme genes from parasites. The parasite metabolic enzyme is the drug target.
(FR) Procédé d'identification de composés utiles en tant que médicaments antiparasites. On ajoute à des micro-organismes déficients des gènes enzymatiques métaboliques homologues à ceux des parasites et venant des parasites. L'enzyme métabolique parasite est la cible du médicament.
Designated States: AU, BB, BG, BR, CA, FI, HU, JP, KP, KR, LK, MC, MG, MW, NO, PL, RO, SD, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1991079750