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1. (WO1991017258) INHIBITORS OF FACTOR XII ACTIVATION AND APPLICATIONS THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017258 International Application No.: PCT/US1991/002990
Publication Date: 14.11.1991 International Filing Date: 01.05.1991
Chapter 2 Demand Filed: 08.10.1991
IPC:
A61K 38/00 (2006.01) ,C07K 7/08 (2006.01) ,C07K 16/36 (2006.01) ,C07K 16/40 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
08
having 12 to 20 amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
36
against blood coagulation factors
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
Applicants:
CETUS CORPORATION [US/US]; 1400 Fifty-Third Street Emeryville, CA 94608, US
NUIJENS, Jan, H. [NL/NL]; NL
HUIJBREGTS, Cecile, C., M. [NL/NL]; NL
HACK, C., Erik [NL/NL]; NL
Inventors:
NUIJENS, Jan, H.; NL
HUIJBREGTS, Cecile, C., M.; NL
HACK, C., Erik; NL
Agent:
GIOTTA, Gregory, J.; Cetus Corporation 1400 Fifty-Third Street Emeryville, CA 94608, US
Priority Data:
521,82010.05.1990US
Title (EN) INHIBITORS OF FACTOR XII ACTIVATION AND APPLICATIONS THEREOF
(FR) INHIBITEURS DE L'ACTIVATION DU FACTEUR XII ET LEURS APPLICATIONS
Abstract:
(EN) Compositions and methods for prophylactically or therapeutically treating sepsis consisting of an inhibitor of Factor XII activation wherein the inhibitor is preferably antibody and has the exemplary properties: binds to and inactivates Factor XII in plasma; substantially inhibits the enzymatic activity of Factor XIIa; and is substantially unreactive with Factor XII-C1 complexes.
(FR) Compositions et procédés de traitement prophylactique ou thérapeutique de la scepticémie comprenant un inhibiteur de l'activation du facteur XII, l'inhibiteur étant de préférence un anticorps et présentant les propriétés suivantes: il se lie au facteur XII qu'il inactive dans du plasma, il inhibe l'activité enzymatique du facteur XIIa, et il ne réagit pas avec des complexes de facteur XII-C1.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0534988CA2082643AU1991077932