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1. (WO1991017242) HUMAN NEURONAL CELL LINE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017242 International Application No.: PCT/US1991/002856
Publication Date: 14.11.1991 International Filing Date: 01.05.1991
Chapter 2 Demand Filed: 29.11.1991
IPC:
A61K 35/30 (2006.01) ,A61P 25/00 (2006.01) ,C12N 5/0793 (2010.01) ,A61K 35/12 (2006.01) ,C12R 1/91 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
30
Nerves; Brain
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
079
Neural cells
0793
Neurons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
R
INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C-C12Q75
1
Micro-organisms
91
Cell lines
Applicants:
THE JOHNS HOPKINS UNIVERSITY [US/US]; 720 Rutland Avenue Baltimore, MD 21205, US
Inventors:
RONNETT, Gabriele, V.; US
NYE, Jeffrey, S.; US
HESTER, Lynda, D.; US
SNYDER, Solomon, H.; US
Agent:
KAGAN, Sarah, A. ; Banner, Birch, McKie & Beckett 1001 G Street, N.W. 11th Floor Washington, DC 20001, US
DOST, Wolfgang; Galileiplatz 1 D-8000 München 80, DE
Priority Data:
515,76001.05.1990US
689,00225.04.1991US
Title (EN) HUMAN NEURONAL CELL LINE
(FR) LIGNEE DE CELLULES NEURONALES HUMAINES
Abstract:
(EN) This invention is directed to continuous, non-malignant, neuronal cell lines, the cells of which: a) in the undifferentiated form are essentially free of branched processes; b) stain positively for neurofilament protein and neurotransmitters; c) do not stain positively for glial fibrillary acidic protein; and d) in the presence of nerve growth factor differentiate into cells with long branched processes. Derivative cell lines of such cell lines are also contemplated. The cell lines are useful in screening methods for evaluation of chemical and biological compounds as well as for therapeutic uses.
(FR) L'invention se rapporte à des lignées de cellules neuronales continues non malignes, dont les cellules: (a) sous leur forme indifférenciée, sont essentiellement exemptes de processus de ramification; (b) prennent le Gram positif pour les protéines neurofilamenteuses et pour les neurotransmetteurs; (c) ne prennent pas le Gram positif pour les protéines acides des fibrilles gliales; et (d) en présence du facteur de croissance nerveuse, se différencient en cellules ayant de longs processus de ramification. Des lignées cellulaires dérivées de ces lignées cellulaires sont également considérées. De telles lignées cellulaires sont utiles dans des procédés de triage pour l'évaluation de composés chimiques et biologiques ainsi que pour des applications thérapeutiques.
Designated States: AU, CA, FI, JP, KR, NO
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0528954JPH05508765CA2081976AU1991078980