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1. (WO1991017186) BETA CELL ANTIGEN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017186 International Application No.: PCT/NL1991/000077
Publication Date: 14.11.1991 International Filing Date: 06.05.1991
Chapter 2 Demand Filed: 03.12.1991
IPC:
A61K 38/00 (2006.01) ,A61K 39/00 (2006.01) ,C07K 14/705 (2006.01) ,C07K 14/725 (2006.01) ,C07K 16/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
725
T-cell receptors
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants:
RIJKSUNIVERSITEIT TE LEIDEN [NL/NL]; Stationsweg 46 NL-2312 AV Leiden, NL (AllExceptUS)
ROEP, Bart, Otto [NL/NL]; NL (UsOnly)
DE VRIES, Rene, Rudolf, Pieter [NL/NL]; NL (UsOnly)
HUTTON, John, Charles [GB/NL]; NL (UsOnly)
Inventors:
ROEP, Bart, Otto; NL
DE VRIES, Rene, Rudolf, Pieter; NL
HUTTON, John, Charles; NL
Agent:
SMULDERS, Th., A., H., J.; Vereenigde Octrooibureaux Nieuwe Parklaan 107 NL-2587 BP The Hague, NL
Priority Data:
900108304.05.1990NL
Title (EN) BETA CELL ANTIGEN
(FR) ANTIGENE DE CELLULE BETA
Abstract:
(EN) Beta cell antigen consisting of an intrinsic transmembrane protein of insulin secretory granules of beta cells located in pancreatic islets of Langerhans, which protein contains an epitope recognised by T-cell clone 1C6. The antigen has a molecular weight of 38 kD. The variable part of the $g(b)-chain of the T-cell receptor of clone 1C6 belongs to the TCR-V$g(b)19 family. Peptide which mimicks said beta cell antigen epitope and can be recognised by T-cell clone 1C6. T-cell which is capable of recognising the beta-cell antigen, receptor of this T-cell, and peptide mimicking this T-cell receptor. Antibody specific for a T-cell which is capable of recognising the beta cell antigen, and antibody specific for the beta cell antigen. Use of one of these substances for type-1 diabetes mellitus diagnostics, monitoring, therapy or prevention.
(FR) Antigène de cellules bêta constitué d'une protéine transmembraneuse intrinsèque des grains de sécrétion d'insuline des cellules bêta situées dans les îlots de Langerhans du pancréas, laquelle protéine renferme un épitope reconnu par le clone 1C6 des lymphocytes T. L'antigène a un poids moléculaire de 38 kD. La partie variable de la chaîne du récepteur de lymphocytes T du clone 1C6 appartient à la famille TCR-V 19. Peptide imitant ledit épitope de l'antigène de cellules bêta et pouvant être reconnu par ledit clone 1C6 des lymphocytes T. Lymphocyte T capable de reconnaître l'antigène de cellules bêta, récepteur de ce lymphocyte T et peptide imitant ce récepteur. Anticorps spécifique pour un lymphocyte T capable de reconnaître l'antigène de cellules bêta, et anticorps spécifique pour ce dernier. Utilisation de l'une de ces substances pour le diagnostic, le contrôle, la thérapie ou la prévention du diabète sucré du type 1.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0528886US20090226930JPH05508395CA2082162DE000069122864AU1991078632
DK0528886