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1. (WO1991017184) MODIFIED INTERLEUKIN-1 INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017184 International Application No.: PCT/US1991/002127
Publication Date: 14.11.1991 International Filing Date: 03.04.1991
Chapter 2 Demand Filed: 21.10.1991
IPC:
A61K 38/00 (2006.01) ,C07K 14/54 (2006.01) ,C07K 14/545 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
54
Interleukins (IL)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
54
Interleukins (IL)
545
IL-1
Applicants:
THE UPJOHN COMPANY [US/US]; 301 Henrietta Street Kalamazoo, MI 49001, US (AllExceptUS)
CARTER, Donald, B. [US/US]; US (UsOnly)
Inventors:
CARTER, Donald, B.; US
Agent:
DELUCA, Mark; The Upjohn Company Corporate Patents & Trademarks Kalamazoo, MI 49001, US
PERRY, Robert, E.; Gill Jennings & Every 53-64 Chancery Lane London WC2A 1HN, GB
Priority Data:
515,46827.04.1990US
Title (EN) MODIFIED INTERLEUKIN-1 INHIBITORS
(FR) INHIBITEURS AMELIORES D'INTERLEUKINE-1
Abstract:
(EN) DNA molecules which encode improved biologically active Interleukin-1 inhibitors are disclosed. DNA molecules that encode improved Interleukin-1 inhibitors incorporated into expression vectors are also disclosed. In addition, host cells transformed with expression vectors that contain DNA molecules encoding improved IL-1 inhibitors and a method of producing improved biologically active IL-1 inhibitors are disclosed. Essentially pure, improved, biologically active IL-1 inhibitors are disclosed.
(FR) L'invention concerne des molécules d'ADN qui codent des inhibiteurs améliorés d'interleukine-1 biologiquement active, ainsi que des molécules d'ADN qui codent des inhibiteurs améliorés d'interleukine-1 incorporés dans des vecteurs d'expression. En outre, des cellules-hôtes transformées avec des vecteurs d'expression qui renferment des molécules d'ADN codant des inhibiteurs améliorés d'IL-1 et un procédé de production d'inhibiteurs améliorés d'IL-1 biologiquement active, sont également présentés. L'invention concerne également des inhibiteurs améliorés et essentiellement purs de IL-1 biologiquement active.
Designated States: AU, BB, BG, BR, CA, FI, HU, JP, KP, KR, LK, MC, MG, MW, NO, PL, RO, SD, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1991076833