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1. (WO1991017177) HIGH AFFINITY ANTIBODIES TO SMALL PEPTIDES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017177 International Application No.: PCT/US1991/003009
Publication Date: 14.11.1991 International Filing Date: 02.05.1991
IPC:
C07K 1/00 (2006.01) ,C07K 16/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
Applicants:
BAXTER DIAGNOSTICS INC. [US/US]; One Baxter Parkway Deerfield, IL 60015, US
Inventors:
BETHELL, Delia, R.; US
JOLLEY, Michael, E.; US
STEVENS, Priscilla, Wilkins; US
Agent:
BARTA, Kent, S. ; One Baxter Parkway Deerfield, IL 60015, US
Priority Data:
519,08104.05.1990US
Title (EN) HIGH AFFINITY ANTIBODIES TO SMALL PEPTIDES
(FR) ANTICORPS DE HAUTE AFFINITE CONTRE DES PETITS PEPTIDES
Abstract:
(EN) High affinity antibodies to small peptides or small peptide epitopes within proteins are prepared by substituting selected amino acids within the antigen combining site which enhance antigen binding affinity. The amino acid substitutions are selected by molecular modelling techniques involving dynamic analysis of the native and substituted structures.
(FR) On prépare des anticorps de haute affinité contre des petits peptides ou des petits épitopes peptidiques se trouvant à l'intérieur de protéines par substitution d'acides aminés sélectionnés à l'intérieur du site de combinaison d'antigènes, lesquels améliorent l'affinité de liaison d'antigènes. On sélectionne les substitutions d'acides aminés à l'aide de techniques de modelage moléculaire mettant en ÷uvre une analyse dynamique des structures natives et substituées.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1991077962