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1. (WO1991017170) MULTIMERIC GELSOLIN FUSION CONSTRUCTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1991/017170 International Application No.: PCT/US1991/002954
Publication Date: 14.11.1991 International Filing Date: 03.05.1991
IPC:
A61K 9/127 (2006.01) ,A61K 38/00 (2006.01) ,A61K 47/48 (2006.01) ,C07K 14/47 (2006.01) ,C07K 14/73 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
725
T-cell receptors
73
CD4
Applicants:
BIOGEN, INC. [US/US]; 14 Cambridge Center Cambridge, MA 02142, US (AllExceptUS)
PEPINSKY, R., Blake [US/US]; US (UsOnly)
ROSA, Margaret, D. [US/US]; US (UsOnly)
STOSSEL, Thomas, P. [US/US]; US (UsOnly)
Inventors:
PEPINSKY, R., Blake; US
ROSA, Margaret, D.; US
STOSSEL, Thomas, P.; US
Agent:
HALEY, James, F., Jr. ; Fish & Neave 875 Third Avenue, 29th Floor New York, NY 10022, US
Priority Data:
520,36804.05.1990US
Title (EN) MULTIMERIC GELSOLIN FUSION CONSTRUCTS
(FR) CONSTRUCTIONS DE FUSION DE GELSOLINE MULTIMERES
Abstract:
(EN) This invention relates to multimeric and hetero-multimeric gelsolin fusion constructs, compositions containing them and methods using them. More particularly, this invention relates to multimeric gelsolin fusion constructs in which at least two gelsolin fusion polypeptides are bound to vesicles containing polyphosphoinositides. This invention also relates to gelsolin fusion polypeptides which comprise gelsolin moieties linked to functional moieties and in particular, to CD4-gelsolin fusion polypeptides comprising an amino acid sequence for a human CD4 protein linked to a gelsolin moiety.
(FR) Constructions de fusion de gelsoline multimères et hétéro-multimères, compositions les renfermant et procédés d'utilisation de ces dernières. L'invention concerne plus particulièrement des constructions de fusion de gelsoline multimères dans lesquelles au moins deux polypeptides de fusion de gelsoline sont liés à des vésicules renfermant des polyphosphoinositides. Cette invention concerne également des polypeptides de fusion de gelsoline qui comprennent des fractions de gelsoline liées à des fractions fonctionnelles, et plus particulièrement des polypeptides de fusion de gelsoline-CD4 comprenant une séquence aminoacide pour une protéine humaine CD4 liée à une fraction de gelsoline.
Designated States: AU, BB, BG, BR, CA, FI, HU, JP, KP, KR, LK, MC, MG, MW, NO, PL, RO, SD, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0481070JPH05501503CA2063593AU1991080861